Fatigue, defined as the failure to maintain the required or expected power output, is a
complex problem, since multiple factors are clearly involved, with the relative importance of …

When a vertebrate skeletal muscle fibre is activated by a nerve impulse, an action potential
spreads from the endplate region along the whole fibre. It enters the transverse tubular …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Microinjection of an expression plasmid that carries complementary DNA encoding the
receptor for dihydropyridine calcium channel blockers of skeletal muscle restores both …

The ryanodine receptor of rabbit skeletal muscle sarcoplasmic reticulum was purified as a
single 450,000-dalton polypeptide from CHAPS-solubilized triads using immunoaffinity …

In skeletal muscle, intramembrane charge movement initiates the processes that lead to the
release of calcium from the sarcoplasmic reticulum. In cardiac muscle, in contrast, the …

The biological mechanisms underlying decline in muscle power and fatigue with age are not
completely understood. The contribution of alterations in the excitation-calcium release …

This is a quantitative model of control of Ca2+ release from the sarcoplasmic reticulum in
skeletal muscle, based on dual control of release channels (ryanodine receptors), primarily …

We celebrate this year the 50th anniversary of the first electrophysiological recordings of the
gating currents from voltage-dependent ion channels done in 1973. This retrospective tries …

In skeletal muscle cells, calcium release to trigger contraction occurs at triads, specialized
junctions where sarcoplasmic reticulum channels are opened by voltage sensors in the …