The molecular physiology of uric acid homeostasis
AK Mandal, DB Mount - Annual review of physiology, 2015 - annualreviews.org
Uric acid, generated from the metabolism of purines, has proven and emerging roles in
human disease. Serum uric acid is determined by production and the net balance of …
human disease. Serum uric acid is determined by production and the net balance of …
The epidemiology and genetics of hyperuricemia and gout across major racial groups: a literature review and population genetics secondary database analysis
F Butler, A Alghubayshi, Y Roman - Journal of personalized medicine, 2021 - mdpi.com
Gout is an inflammatory condition caused by elevated serum urate (SU), a condition known
as hyperuricemia (HU). Genetic variations, including single nucleotide polymorphisms …
as hyperuricemia (HU). Genetic variations, including single nucleotide polymorphisms …
The genetics of hyperuricaemia and gout
Gout is a common and very painful inflammatory arthritis caused by hyperuricaemia. This
Review provides an update on the genetics of hyperuricaemia and gout, including findings …
Review provides an update on the genetics of hyperuricaemia and gout, including findings …
Gout: a review of nonmodifiable and modifiable risk factors
LA MacFarlane, SC Kim - Rheumatic Disease Clinics, 2014 - rheumatic.theclinics.com
Gout is one of the most common inflammatory arthritides, caused by hyperuricemia, with an
increasing prevalence. Hyperuricemia is often a consequence of renal underexcretion of …
increasing prevalence. Hyperuricemia is often a consequence of renal underexcretion of …
The genetic basis of hyperuricaemia and gout
TR Merriman, N Dalbeth - Joint Bone Spine, 2011 - Elsevier
Gout results from elevated urate concentrations in the blood (hyperuricaemia). When super-
saturation of urate is reached, monosodium urate crystals form within the joint. In some …
saturation of urate is reached, monosodium urate crystals form within the joint. In some …
A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Māori, case and control sample sets
AJ Phipps-Green, JE Hollis-Moffatt… - Human molecular …, 2010 - academic.oup.com
Genetic variation in ABCG2 (rs2231142, Q141K), encoding a uric acid transporter, is
associated with gout in diverse populations. The aim of this study was to examine a role for …
associated with gout in diverse populations. The aim of this study was to examine a role for …
Evaluation of the Influence of Genetic Variants of SLC2A9 (GLUT9) and SLC22A12 (URAT1) on the Development of Hyperuricemia and Gout
K Pavelcova, J Bohata, M Pavlikova… - Journal of clinical …, 2020 - mdpi.com
Urate transporters, which are located in the kidneys, significantly affect the level of uric acid
in the body. We looked at genetic variants of genes encoding the major reabsorption …
in the body. We looked at genetic variants of genes encoding the major reabsorption …
Recent advances in renal urate transport: characterization of candidate transporters indicated by genome-wide association studies
N Anzai, P Jutabha… - Clinical and …, 2012 - Springer
Humans have higher serum uric acid levels than other mammalian species owing to the
genetic silencing of the hepatic enzyme uricase that metabolizes uric acid into allantoin …
genetic silencing of the hepatic enzyme uricase that metabolizes uric acid into allantoin …
[HTML][HTML] Genotype-based changes in serum uric acid affect blood pressure
Elevated serum levels of uric acid consistently correlate with hypertension, but the
directionality of the association remains debated. To help define this relationship, we used a …
directionality of the association remains debated. To help define this relationship, we used a …
Hyperuricemia, gout and the kidney
T Gibson - Current opinion in rheumatology, 2012 - journals.lww.com
Renal tubular handling of uric acid is dependent on tubular transporters, one of which is
GLUT9. Mutations of its gene SLC2A9 are associated with aberrations of uric acid disposal …
GLUT9. Mutations of its gene SLC2A9 are associated with aberrations of uric acid disposal …