Guanylyl cyclases are a family of enzymes that catalyze the conversion of GTP to cGMP. The
family comprises both membrane-bound and soluble isoforms that are expressed in nearly …

In the past few years, nuclear DNA damage-sensing mechanisms activated by ionizing
radiation have been identified, including ATM/ATR and the DNA-dependent protein kinase …

cGMP is a second messenger that produces its effects by interacting with intracellular
receptor proteins. In smooth muscle cells, one of the major receptors for cGMP is the …

Long-term potentiation (LTP) in the hippocampus has an early phase (E-LTP) that can be
induced by one-or two-train tetanization, lasts∼ 1 hr, and is cAMP-dependent protein kinase …

Abstract cGMP-dependent protein kinases I and II conduct signals from widespread
signaling systems. Whereas the type I kinase mediates numerous effects of natriuretic …

Signaling cascades initiated by nitric oxide (NO) and natriuretic peptides (NPs) play an
important role in the maintenance of cardiovascular homeostasis. It is currently accepted that …

Cyclic GMP, produced in response to nitric oxide and natriuretic peptides, is a key regulator
of vascular smooth muscle cell contractility, growth, and differentiation, and is implicated in …

Amyloid-β (Aβ), a peptide thought to play a crucial role in Alzheimer's disease (AD), has
many targets that, in turn, activate different second-messenger cascades. Interestingly, Aβ …

Cyclic AMP (cAMP) and cyclic GMP (cGMP) are key second messengers involved in a
multitude of cellular events. From the wealth of synthetic analogs of cAMP and cGMP, only a …

Nitric oxide (NO) is widespread in the nervous system and is thought to play a role in a
variety of different neuronal functions, including learning and memory (see other chapters …