Cytoskeleton-modulating nanomaterials and their therapeutic potentials

J Park, Y Wu, JS Kim, J Byun, J Lee, YK Oh - Advanced Drug Delivery …, 2024 - Elsevier
The cytoskeleton, an intricate network of protein fibers within cells, plays a pivotal role in
maintaining cell shape, enabling movement, and facilitating intracellular transport. Its …

Engineered nanoparticles for clinical assays

J Cheong, A Jo, J Lee, S Lee, J Lee, JH Lee… - Nature Reviews …, 2024 - nature.com
Nanoparticles exhibit distinctive physical and chemical properties that make them effective
mediators for optical, magnetic or electric signal transduction. Consequently, nanoparticles …

Glycopolymeric Nanoparticles Enrich Less Immunogenic Protein Coronas, Reduce Mononuclear Phagocyte Clearance, and Improve Tumor Delivery Compared to …

K Hulugalla, O Shofolawe-Bakare, VB Toragall… - ACS …, 2024 - ACS Publications
Nanoparticles (NPs) offer significant promise as drug delivery vehicles; however, their in
vivo efficacy is often hindered by the formation of a protein corona (PC), which influences …

Biodistribution and therapeutic efficacy of a gold nanoparticle-based targeted drug delivery system against pancreatic cancer

CK Elechalawar, SK Gulla, RV Roy, N Means, Y Zhang… - Cancer Letters, 2024 - Elsevier
Pancreatic cancer is characterized by desmoplasia; crosstalk between pancreatic cancer
cells (PCCs) and pancreatic stellate cells (PSCs) leads to the deposition of extracellular …

Stereoselective coronas regulate the fate of chiral gold nanoparticles in vivo

D Baimanov, L Wang, K Liu, M Pan, R Cai… - Nanoscale …, 2023 - pubs.rsc.org
It is unknown how the identity provided by protein coronas on the surface of chiral
nanoparticles determines their blood circulation, distribution, and clearance fates of the …

Combination of Chemical and Physical Cancer Therapeutics Developed with Microcapsules Made of κ-Casein and Gold Nanoparticles in the Presence of Drug …

Y Ha, S An, SR Paik - ACS Applied Materials & Interfaces, 2024 - ACS Publications
Tumor heterogeneity requires development of an anticancer system equipped with both
chemical and physical therapeutics to eradicate cancer exhibiting drug resistance and …

Peptide Orientation Strongly Affected by the Nanoparticle Size as Revealed by Sum Frequency Scattering Spectroscopy

TW Golbek, T Weidner - The Journal of Physical Chemistry Letters, 2023 - ACS Publications
The orientation of proteins at interfaces has a profound effect on the function of proteins. For
nanoparticles (NPs) in a biological environment, protein orientation determines the toxicity …

Protein Binding Leads to Reduced Stability and Solvated Disorder in the Polystyrene Nanoparticle Corona

RP Somarathne, DL Amarasekara, CS Kariyawasam… - Small, 2024 - Wiley Online Library
Understanding the conformation of proteins in the nanoparticle corona has important
implications in how organisms respond to nanoparticle‐based drugs. These proteins coat …

Coarse-grained simulations of lysozyme-silica-nanoparticle corona

L Qin, G Yu, J Zhou - Biointerphases, 2023 - pubs.aip.org
Protein coronas, formed by proteins and nanomaterials, have various applications in the
biomedical field. Here, large-scale simulations of protein coronas have been carried out by …

Rapid and Specific Detection of Bacillus cereus Using Phage Protein-Based Lateral Flow Assays

G Le Brun, M Nuytten, A Leprince, K Glinel… - ACS Applied Bio …, 2024 - ACS Publications
Rapid and precise diagnostic techniques are essential for identifying foodborne pathogens,
including Bacillus cereus (B. cereus), which poses significant challenges to food safety …