Decarboxylative halogenation, or halodecarboxylation, represents one of the fundamental
key methods for the synthesis of ubiquitous organic halides. The method is based on …

Antifolates are the oldest of the antimetabolite class of anticancer agents and were one of
the first modern anticancer drugs. The first clinically useful antifolate, described in 1947, was …

A new class of very potent inhibitors of cytosol leucine aminopeptidase (LAP), a member of
the metalloprotease family, is described. The X-ray structure of bovine lens leucine …

A mild and highly stereoselective rhodium (II)-catalyzed cyclopropanation of alkenes,
alkynes, and allenes with diacceptor diazo compounds is reported. Using the phosphonate …

A century after their discovery, phosphonates have become important compounds
recognized both for their use as efficient reagents in organic synthesis and for their …

An efficient oxygen–phosphoryl bond-forming reaction via iron-catalyzed cross
dehydrogenative coupling has been developed. This transformation proceeds efficiently …

Over the course of the last decades, phosphinic peptides have emerged as an extremely
important class of Zn-metalloprotease inhibitors. The intense interest in these compounds in …

Recent post hoc analyses of several clinical trials with P2Y12 antagonists showed the need
for new molecules being fully efficacious as antiplatelet agents and having a reduced …

Some novel amidate prodrugs of PMEA and PMPA have been synthesised and tested in
vitro for their biological activity. Compound 5 in particular showed greatly enhanced antiviral …

Reaction of folic acid (1) with excess trifluoroacetic anhydride provides access to both the
previously unknown N 10-(trifluoroacetyl) pyrofolic acid (8) and pyrofolic acid (9). Reaction …