Plants represent the main source of molecules for the development of new drugs, which
intensifies the interest of transnational industries in searching for substances obtained from …

The development of novel synthetic strategies to form new chemical entities in a
stereoselective manner is an ongoing significant objective in organic and medicinal …

Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …

Spiroindole and spirooxindole scaffolds are very important spiro-heterocyclic compounds in
drug design processes. Significant attention has been directed at obtaining molecules …

The p53 gene, a well-known tumor suppressor gene, plays a crucial role in cell cycle
regulation, DNA repair, cell differentiation, and apoptosis. MDM2 exerts p53-dependent …

Pyrrolidine molecules are a significant class of synthetic and natural plant metabolites,
which show the diversity of pharmacological activities. An extensive variety of synthetic …

The tumor resistance to p53 activators posed a clinical challenge. Combination studies
disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and …

MDM2 and MDM4 are key negative regulators of p53, an important protein involved in
several cell processes (eg cell cycle and apoptosis). Not surprisingly, the p53 tumor …

Despite the achieved progress in develo** efficient MDM2-p53 protein-protein interaction
inhibitors (MDM2 inhibitors), the acquired resistance of tumor cells to such p53 activators …

Cancer represents one of the world's biggest hazardous diseases. p53 is the uttermost
researched tumour suppressor protein. It is commonly considered the “guardian of the …