Electrophysiological characterization of live human tissue from epilepsy patients has been
performed for many decades. Although initially these studies sought to understand the …

Aging-related impairments in hippocampus-dependent cognition have been attributed to
maladaptive changes in the functional properties of pyramidal neurons within the …

Sharp wave‐ripple complexes (SPW‐Rs) are spontaneous oscillatory events that
characterize hippocampal activity during resting periods and slow‐wave sleep. SPW‐Rs are …

The incidence of seizures increases with old age. Stroke, dementia and brain tumors are
recognized risk factors for new-onset seizures in the aging populations and the incidence of …

Epilepsy is a chronic neurological disorder characterized by spontaneous recurrent seizures
(SRS) and comorbidities. Kindling through repetitive brief stimulation of a limbic structure is …

Aging is accompanied by a complicated pattern of changes in the brain organization and
often by alterations in specific memory functions. One of the brain activities with important …

The hippocampal circuitry is widely recognized as susceptible to ischemic injury and seizure
generation. However, hippocampal contribution to acute non-convulsive seizures (NCS) in …

Background Rodent brain slices—particularly hippocampal slices—are widely used in
experimental investigations of epileptiform activity. Oxygenated artificial cerebrospinal fluid …

I hereby declare that this thesis contains no material that has been accepted for the award of
any other degree or diploma, and to the best of my knowledge, this thesis is original and …