In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced
histamine release from rabbit platelets producing antibodies in passive cutaneous …

Platelet-activating factor (PAF) is a phospholipid mediator that belongs to a family of
biologically active, structurally related alkyl phosphoglycerides. PAF acts via a specific …

Platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) is a
biologically active phospholipid mediator. Although PAF was initially recognized for its …

During the past two decades, studies describing the chemistry and biology of PAF have
been extensive. This potent phosphoacylglycerol exhibits a wide variety of physiological and …

Platelet-activating factor (PAF-acether), an inflammatory mediator with a wide range of
biological activities including neutrophil aggregation and chemotaxis, was studied for its …

Serum contains a factor that co-purifies with albumin and causes neurite retraction in PC12
cells, inhibits the proliferation of tumor cells in vitro, and activates the phosphatidylinositol …

Platelet-activating factor (PAF) is a potent phospholipid mediator with diverse biological
activities in addition to its well-known ability to stimulate platelet aggregation. Pharmacologic …

Cultured human endothelial cells produce platelet-activating factor (1-alkyl-2-acetyl-sn-
glycero-3-phosphocholine; PAF) when stimulated with human thrombin. The response to …

Platelet-activating factor (PAF) acetylhydrolase has been recognized as an enzyme that
inactivates PAF. We developed a convenient and reproducible method for determining …

1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine, a phospholipid with platelet activating and
hypotensive properties, has an extremely labile acetate grou**. The acetate group is …