The mechanisms responsible for the antiproliferative and cytotoxic effects of the
anthracycline antibiotics doxorubicin (Adriamycin®) and daunorubicin (daunomycin) have …

It is generally accepted that recent advances in anticancer agents have contributed
significantly to the improvement of both the disease-free survival and quality of life in cancer …

In recent years, there has been an increased understanding of P-glycoprotein (P-GP)-
mediated pharmacokinetic interactions. In addition, its role in modifying the bioavailability of …

The antineoplastic drug doxorubicin is capable of generating a variety of free radical species
in subcellular systems and this capacity has been considered critical for its antitumor action …

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

Objectives The use of doxorubicin, a drug utilised for many years to treat a wide variety of
cancers, has long been limited due to the significant toxicity that can occur not only during …

Development of multidrug resistance (MDR) against a variety of conventional and novel
chemotherapeutic agents is a significant challenge in effective cancer therapy. Over the last …

Multidrug resistance (MDR) in tumor has long been considered a major factor in the failure
of tumor chemotherapy. P-glycoprotein (P-gp)-mediated drug efflux plays a significant role in …

The alkylating agents are antitumor drugs that act through the covalent binding of alkyl
groups to cellular molecules. This binding is mediated by reactive intermediates formed from …

This study demonstrates that the flavonoid quercetin (Q), a plant-derived compound with low
toxicity in vivo, greatly potentiates the growth-inhibitory activity of Adriamycin (ADR) on MCF …