Genetic causes of spermatogenic failure
A Massart, W Lissens, H Tournaye… - Asian journal of …, 2011 - pmc.ncbi.nlm.nih.gov
Approximately 10%–15% of couples are infertile, and a male factor is involved in almost half
of these cases. This observation is due in part to defects in spermatogenesis, and the …
of these cases. This observation is due in part to defects in spermatogenesis, and the …
HSP90AB1: Hel** the good and the bad
M Haase, G Fitze - Gene, 2016 - Elsevier
HSP90AB1 (heat shock protein 90 kDA alpha, class B, member 1), also known as
HSP90beta, is a member of the large family of HSPs which function as molecular …
HSP90beta, is a member of the large family of HSPs which function as molecular …
Novel endogenous angiogenesis inhibitors and their therapeutic potential
Angiogenesis, the formation of new blood vessels from the pre-existing vasculature is
essential for embryonic development and tissue homeostasis. It also plays critical roles in …
essential for embryonic development and tissue homeostasis. It also plays critical roles in …
A placenta-on-a-chip model to determine the regulation of FKBPL and galectin-3 in preeclampsia
SM Ghorbanpour, C Richards, D Pienaar… - Cellular and Molecular …, 2023 - Springer
Preeclampsia is a pregnancy-specific cardiovascular disorder, involving significant maternal
endothelial dysfunction. Although inappropriate placentation due to aberrant angiogenesis …
endothelial dysfunction. Although inappropriate placentation due to aberrant angiogenesis …
RALA-mediated delivery of FKBPL nucleic acid therapeutics
R Bennett, A Yakkundi, HD McKeen… - …, 2015 - Taylor & Francis
Aims: RALA is a novel 30 mer bioinspired amphipathic peptide that is showing promise for
gene delivery. Here, we used RALA to deliver the FK506-binding protein like–FKBPL gene …
gene delivery. Here, we used RALA to deliver the FK506-binding protein like–FKBPL gene …
Targeting treatment-resistant breast cancer stem cells with FKBPL and its peptide derivative, AD-01, via the CD44 pathway
Purpose: FK506-binding protein like (FKBPL) and its peptide derivative, AD-01, have
already shown tumor growth inhibition and CD44-dependent antiangiogenic activity. Here …
already shown tumor growth inhibition and CD44-dependent antiangiogenic activity. Here …
FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer
S Annett, G Moore, A Short, A Marshall… - British Journal of …, 2020 - nature.com
Background ALM201 is a therapeutic peptide derived from FKBPL that has previously
undergone preclinical and clinical development for oncology indications and has completed …
undergone preclinical and clinical development for oncology indications and has completed …
De novo mutations in idiopathic male infertility—A pilot study
Study question Are de novo mutations in the human genome associated with male infertility?
Summary answer We identified de novo mutations in five candidate genes: SEMA5A …
Summary answer We identified de novo mutations in five candidate genes: SEMA5A …
Vitamins C and D exhibit similar antidepressant effects to escitalopram mediated by NOx and FKBPL in a stress-induced mice model
The aim of this study was to investigate the potential antidepressant and anxiolytic effects of
vitamin C and vitamin D in a stress-induced mouse model of depression, while also …
vitamin C and vitamin D in a stress-induced mouse model of depression, while also …
Characterisation of cardiac health in the reduced uterine perfusion pressure model and a 3D cardiac spheroid model, of preeclampsia
C Richards, K Sesperez, M Chhor… - Biology of sex …, 2021 - Springer
Background Preeclampsia is a dangerous cardiovascular disorder of pregnancy that leads
to an increased risk of future cardiovascular and metabolic disorders. Much of the …
to an increased risk of future cardiovascular and metabolic disorders. Much of the …