The epithelial-mesenchymal transition (EMT) is intrinsically linked to alterations of the
intracellular cytoskeleton and the extracellular matrix. After EMT, cells acquire an elongated …

It is widely accepted that three-dimensional cell culture systems simulate physiological
conditions better than traditional 2D systems. Although extracellular matrix components …

Silk fibroin (SF) from Bombyx mori silkworm has been used as a textile fiber for centuries. In
addition, for decades, SF has been used as a suture material. SF's unique properties, such …

The establishment of tumor microenvironment using biomimetic in vitro models that
recapitulate key tumor hallmarks including the tumor supporting extracellular matrix (ECM) is …

Cell traction force plays a critical role in directing cellular functions, such as proliferation,
migration, and differentiation. Current understanding of cell traction force is largely derived …

Clinical evidence supports a role for the extracellular matrix (ECM) in cancer plasticity
across multiple tumor types. The lack of in vitro models that represent the native ECMs is a …

Cellular processes are initiated and regulated by different stimuli, including mechanical
forces. Cell membrane mechanosensors represent the first step towards the conversion of …

Biophysical stimuli including topography play a crucial role in the regulation of cell
morphology, adhesion, migration, and cytoskeleton organization and have been known to …

Breast cancer (BC) metastasis is an enormous challenge targeting BC therapy. The
extracellular matrix (ECM), the principal component of the BC metastasis niche, is the pivotal …

Breast cancer (BCa) is one of the most common cancers for women and metastatic BCa
causes the majority of deaths. The extracellular matrix (ECM) stiffens during cancer …