[HTML][HTML] Schizophrenia, dopamine and the striatum: from biology to symptoms
The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …
Animal models of neuropsychiatric disorders
Modeling of human neuropsychiatric disorders in animals is extremely challenging given the
subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests …
subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests …
Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
[HTML][HTML] Integrating the neurodevelopmental and dopamine hypotheses of schizophrenia and the role of cortical excitation-inhibition balance
OD Howes, E Shatalina - Biological psychiatry, 2022 - Elsevier
The neurodevelopmental and dopamine hypotheses are leading theories of the
pathoetiology of schizophrenia, but they were developed in isolation. However, since they …
pathoetiology of schizophrenia, but they were developed in isolation. However, since they …
Glutamate and dopamine in schizophrenia: An update for the 21st century
O Howes, R McCutcheon… - Journal of …, 2015 - journals.sagepub.com
The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …
Economics and mental health: the current scenario
Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
The role of genes, stress, and dopamine in the development of schizophrenia
The dopamine hypothesis is the longest standing pathoetiologic theory of schizophrenia.
Because it was initially based on indirect evidence and findings in patients with established …
Because it was initially based on indirect evidence and findings in patients with established …
The nature of dopamine dysfunction in schizophrenia and what this means for treatment: meta-analysis of imaging studies
Context Current drug treatments for schizophrenia are inadequate for many patients, and
despite 5 decades of drug discovery, all of the treatments rely on the same mechanism …
despite 5 decades of drug discovery, all of the treatments rely on the same mechanism …
Antipsychotics: mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology
Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …
disorders but are ineffective for some patients and associated with side-effects and …
Neuroimaging biomarkers in schizophrenia
NV Kraguljac, WM McDonald… - American Journal of …, 2021 - Am Psychiatric Assoc
Schizophrenia is a complex neuropsychiatric syndrome with a heterogeneous genetic,
neurobiological, and phenotypic profile. Currently, no objective biological measures—that is …
neurobiological, and phenotypic profile. Currently, no objective biological measures—that is …