Sporadic colorectal cancer has traditionally been viewed as a malignancy of older
individuals. However, as the global prevalence of the disease diagnosed in younger …

Background The role of adjuvant chemotherapy for patients with rectal cancer after
preoperative (chemo) radiotherapy and surgery is uncertain. We did a meta-analysis of …

This selection from the NCCN Guidelines for Rectal Cancer focuses on management of
malignant polyps and resectable nonmetastatic rectal cancer because important updates …

PURPOSE To ascertain if preoperative short-term radiotherapy followed by chemotherapy is
not inferior to a standard schedule of long-term chemoradiotherapy in patients with locally …

PURPOSE Total neoadjuvant therapy is a new paradigm for rectal cancer treatment. Optimal
scheduling of preoperative chemoradiotherapy (CRT) and chemotherapy remains to be …

The incidence of rectal cancer in the European Union is∼ 125 000 per year, ie∼ 35% of the
total colorectal cancer incidence, reflecting 15–25 cases/100 000 population per year and is …

Background Treatment of locally advanced rectal cancer with chemoradiotherapy, surgery,
and adjuvant chemotherapy controls local disease, but distant metastases remain common …

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Rectal Cancer
address diagnosis, staging, surgical management, perioperative treatment, management of …

Background Systemic relapses remain a major problem in locally advanced rectal cancer.
Using short-course radiotherapy followed by chemotherapy and delayed surgery, the Rectal …

Objective For patients with locally advanced rectal cancer (LARC), adjuvant chemotherapy
selection following surgery remains a major clinical dilemma. Here, we investigated the …