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Mechanisms of hepatocyte injury, multiorgan failure, and prognostic criteria in acute liver failure
SM Riordan, R Williams - Seminars in liver disease, 2003 - thieme-connect.com
Acute liver failure (ALF) occurs when the rate and extent of liver cell death are not
adequately balanced by regenerative activity. Two forms of liver cell death are recognized …
adequately balanced by regenerative activity. Two forms of liver cell death are recognized …
Acute liver failure: targeted artificial and hepatocyte-based support of liver regeneration and reversal of multiorgan failure
SM Riordan, R Williams - Journal of Hepatology, 2000 - Elsevier
Acute liver failure (ALF) still represents a major therapeutic challenge for hepatologists due
to its high mortality rate as a result of multiorgan failure. Although emergency orthotopic liver …
to its high mortality rate as a result of multiorgan failure. Although emergency orthotopic liver …
Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-γ)
Background & Aims: Hepatic lymphocytes are composed mainly of natural killer (NK) cells
and NKT cells, which play key roles in innate immune responses against pathogens and …
and NKT cells, which play key roles in innate immune responses against pathogens and …
Nonparenchymal cells from regenerating rat liver generate interleukin-1α and-1β: a mechanism of negative regulation of hepatocyte proliferation
Following experimental partial hepatectomy of 70% in the rat, there is a semisynchronized
surge of hepatocyte proliferation that ceases after 48 to 72 hours. Little is known about the …
surge of hepatocyte proliferation that ceases after 48 to 72 hours. Little is known about the …
Alginate‐encapsulated HepG2 cells in a fluidized bed bioreactor maintain function in human liver failure plasma
Alginate‐encapsulated HepG2 cells cultured in microgravity have the potential to serve as
the cellular component of a bioartificial liver. This study investigates their performance in …
the cellular component of a bioartificial liver. This study investigates their performance in …
Decreasing serum alpha-fetoprotein levels in predicting poor prognosis of acute hepatic failure in patients with chronic hepatitis B
Background: Background: We carried out a study to predict the prognosis of acute hepatic
failure in patients with chronic hepatitis B. Methods: We studied 25 consecutive patients with …
failure in patients with chronic hepatitis B. Methods: We studied 25 consecutive patients with …
Extra-corporeal non-liver transplant therapies for acute liver failure: focus on plasma exchange and continuous renal replacement therapy
The acute inflammatory milieu in patients with acute liver failure (ALF) results in 'toxic'blood
in these patients. In vitro experiments have shown that the plasma obtained from ALF …
in these patients. In vitro experiments have shown that the plasma obtained from ALF …
Use of bioartificial and artificial liver support devices
RD Hughes, R Williams - Seminars in liver disease, 1996 - thieme-connect.com
With all the new work and current interest in extracorporeal liver support systems
incorporating hepatocytes, the findings with earlier artificial systems need to be …
incorporating hepatocytes, the findings with earlier artificial systems need to be …
Extracorporeal support and hepatocyte transplantation in acute liver failure and cirrhosis
SM Riordan, R Williams - Journal of gastroenterology and …, 1999 - Wiley Online Library
The relative shortage of donor organs and lack of immediate availability mean that many
patients with acute liver failure die before orthotopic liver transplantation can be performed …
patients with acute liver failure die before orthotopic liver transplantation can be performed …
Activin A and follistatin in acute liver failure
RD Hughes, LW Evans - European journal of gastroenterology & …, 2003 - journals.lww.com
Background Liver regeneration may be impaired in acute liver failure due to either inhibition
of the proliferative response or ongoing liver cell death. Activin A, a member of the TGFβ …
of the proliferative response or ongoing liver cell death. Activin A, a member of the TGFβ …