The intercellular communication between osteoblasts and osteoclasts is crucial to bone
homeostasis. Since Rodan and Martin proposed the control of osteoclasts by osteoblasts in …

The vacuolar-type H+-ATPase (V-ATPase) proton pump is a macromolecular complex
composed of at least 14 subunits organized into two functional domains, V1 and V0. The …

We studied the effect of proton pump inhibitors, histamine H 2 receptor antagonists, and
other types of antacid drugs on fracture risk. All cases were subjects with any fracture …

Tumor cells thrive in a hypoxic microenvironment with an acidic extracellular pH. To survive
in this harsh environment, tumor cells must exhibit a dynamic cytosolic pH regulatory system …

Stimuli‐responsive gene delivery systems maximize therapeutic efficacy by controlling the
cytosolic conveyance and rate of effective gene release. We present herein a hybrid …

Eukaryotic cells have evolved a family of ATP-dependent proton pumps known as the
vacuolar (H+)-ATPases (or V-ATPases) to regulate the pH of intracellular compartments, the …

Acidity is one of the main features of the tumors. The V-ATPase is the primary responsible for
the control of tumor microenvironment by proton extrusion to the extracellular medium. The …

We report a novel gene for a parkinsonian disorder. X-linked parkinsonism with spasticity
(XPDS) presents either as typical adult onset Parkinson's disease or earlier onset spasticity …

Bone resorption is an important cellular function in the development and physiology of the
skeleton. Pathophysiology of several skeletal diseases includes either increased (for …

RNA interference (RNAi) is a highly conserved gene regulatory mechanism in eukaryotic
organisms; however, an understanding of mechanisms of cellular uptake of double-stranded …