(Patho) physiology of glycosylphosphatidylinositol-anchored proteins I: Localization at plasma membranes and extracellular compartments
GA Müller, TD Müller - Biomolecules, 2023 - mdpi.com
Glycosylphosphatidylinositol (GPI)-anchored proteins (APs) are anchored at the outer leaflet
of plasma membranes (PMs) of all eukaryotic organisms studied so far by covalent linkage …
of plasma membranes (PMs) of all eukaryotic organisms studied so far by covalent linkage …
The release of glycosylphosphatidylinositol-anchored proteins from the cell surface
GA Müller - Archives of biochemistry and biophysics, 2018 - Elsevier
Starting with the first description of the anchorage of a subset of cell surface proteins in
eukaryotic cells from yeast to mammals with the aid of a glycosylphosphatidylinositol (GPI) …
eukaryotic cells from yeast to mammals with the aid of a glycosylphosphatidylinositol (GPI) …
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells
The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that
promotes tissue remodeling, tumor cell adhesion, migration and invasion. uPAR mediates …
promotes tissue remodeling, tumor cell adhesion, migration and invasion. uPAR mediates …
[HTML][HTML] The six-transmembrane enzyme GDE2 is required for the release of molecularly distinct small extracellular vesicles from neurons
KT Shuler, J Llamas-Rodriguez, R Levy-Myers… - Cells, 2024 - mdpi.com
Extracellular vesicles (EVs) are implicated in a multitude of physiological and
pathophysiological processes in the nervous system; however, their biogenesis and cargoes …
pathophysiological processes in the nervous system; however, their biogenesis and cargoes …
Wnt signalling facilitates neuronal differentiation of cochlear Frizzled10-positive cells in mouse cochlea via glypican 6 modulation
M Wang, Y Han, W An, X Wang, F Chen, J Lu… - Cell Communication and …, 2025 - Springer
Degeneration of cochlear spiral ganglion neurons (SGNs) leads to irreversible
sensorineural hearing loss (SNHL), as SGNs lack regenerative capacity. Although cochlear …
sensorineural hearing loss (SNHL), as SGNs lack regenerative capacity. Although cochlear …
An integrative network analysis framework for identifying molecular functions in complex disorders examining major depressive disorder as a test case
AM Oommen, S Cunningham, PS O'Súilleabháin… - Scientific Reports, 2021 - nature.com
In addition to the psychological depressive phenotype, major depressive disorder (MDD)
patients are also associated with underlying immune dysregulation that correlates with …
patients are also associated with underlying immune dysregulation that correlates with …
GDE6 promotes progenitor identity in the vertebrate neural tube
M McKean, FR Napoli, T Hasan, T Joseph… - Frontiers in …, 2023 - frontiersin.org
The generation of neurons in the central nervous system is a complex, stepwise process
necessitating the coordinated activity of mitotic progenitors known as radial glia. Following …
necessitating the coordinated activity of mitotic progenitors known as radial glia. Following …
A likely pathogenic variant putatively affecting splicing of PIGA identified in a multiple congenital anomalies hypotonia‐seizures syndrome 2 (MCAHS2) family …
J Yang, Q Wang, Q Zhuo, H Tian, W Li… - … Genetics & Genomic …, 2018 - Wiley Online Library
Background Glycosylphosphatidylinositol (GPI) anchoring is a special type of protein
posttranslational modification, by which proteins with diverse function are attached to cell …
posttranslational modification, by which proteins with diverse function are attached to cell …
Spatiotemporal patterns of menin localization in develo** murine brain: co-expression with the elements of cholinergic synaptic machinery
Menin, a product of MEN1 (multiple endocrine neoplasia type 1) gene is an important
regulator of tissue development and maintenance; its perturbation results in multiple tumors …
regulator of tissue development and maintenance; its perturbation results in multiple tumors …
Expression of Gas1 in mouse brain: Release and role in neuronal differentiation
E Bautista, N Zarco, N Aguirre-Pineda… - Cellular and Molecular …, 2018 - Springer
Abstract Growth arrest-specific 1 (Gas1) is a pleiotropic protein that induces apoptosis of
tumor cells and has important roles during development. Recently, the presence of two …
tumor cells and has important roles during development. Recently, the presence of two …