Mitochondrial metabolism is an important contributor to cancer cell survival and proliferation
that coexists with enhanced glycolytic activity. Measuring mitochondrial activity is useful to …

Autofluorophores are endogenous fluorescent compounds that naturally occur in the intra
and extracellular spaces of all tissues and organs. Most have vital biological functions–like …

Safely maximizing brain cancer removal without injuring adjacent healthy tissue is crucial for
optimal treatment outcomes. However, it is challenging to distinguish cancer from noncancer …

Second Harmonic Generation Microscopy (SHG) is widely acknowledged as a valuable non-
linear optical imaging tool, its contrast mechanism providing the premises to non-invasively …

Abstract Purpose Artificial Intelligence (AI) involves several and different techniques able to
elaborate a large amount of data responding to a specific planned outcome. There are …

Purpose Analysis of autofluorescence holds promise for brain tumor delineation and
diagnosis. Therefore, we investigated the potential of a commercial confocal laser scanning …

Abstract Background Hematoxylin and Eosin (H&E)-based frozen section (FS) pathology is
presently the global standard for intraoperative tumor assessment (ITA). Preparation of …

Glioblastoma tumor recurrences often occur in brain tissue areas harboring infiltrating tumor
cells, resembling healthy tissue in brain imaging. Demarcating infiltrative regions for …

Interstitial lung disease (ILD), characterized by inflammation and fibrosis, often suffers from
low diagnostic accuracy and consistency. Traditional hematoxylin and eosin (H&E) staining …

Optical imaging is crucial for cell examination, but its instruments' bulky optics limit their
flexibility, and a single wavelength provides limited sample information. This paper presents …