Advances in the pathogenesis of psoriasis: from keratinocyte perspective
X Zhou, Y Chen, L Cui, Y Shi, C Guo - Cell death & disease, 2022 - nature.com
Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and
associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration …
associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration …
Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis
K Ghoreschi, A Balato, C Enerbäck, R Sabat - The Lancet, 2021 - thelancet.com
Psoriasis is a chronic inflammatory disease characterised by sharply demarcated
erythematous and scaly skin lesions accompanied by systemic manifestations. Classified by …
erythematous and scaly skin lesions accompanied by systemic manifestations. Classified by …
[HTML][HTML] Psoriasis: a brief overview
Psoriasis is a clinically heterogeneous lifelong skin disease that presents in multiple forms
such as plaque, flexural, guttate, pustular or erythrodermic. An estimated 60 million people …
such as plaque, flexural, guttate, pustular or erythrodermic. An estimated 60 million people …
[HTML][HTML] Atopic dermatitis is an IL-13–dominant disease with greater molecular heterogeneity compared to psoriasis
LC Tsoi, E Rodriguez, F Degenhardt, H Baurecht… - Journal of Investigative …, 2019 - Elsevier
Atopic dermatitis (AD) affects up to 20% of children and adults worldwide. To gain a deeper
understanding of the pathophysiology of AD, we conducted a large-scale transcriptomic …
understanding of the pathophysiology of AD, we conducted a large-scale transcriptomic …
The genetic basis of psoriasis
F Capon - International journal of molecular sciences, 2017 - mdpi.com
Psoriasis is widely regarded as a multifactorial condition which is caused by the interaction
between inherited susceptibility alleles and environmental triggers. In the last decade …
between inherited susceptibility alleles and environmental triggers. In the last decade …
[HTML][HTML] Clinical and genetic differences between pustular psoriasis subtypes
Background The term pustular psoriasis indicates a group of severe skin disorders
characterized by eruptions of neutrophil-filled pustules. The disease, which often manifests …
characterized by eruptions of neutrophil-filled pustules. The disease, which often manifests …
[HTML][HTML] Role of IL-36 cytokines in psoriasis and other inflammatory skin conditions
KL Sachen, CNA Greving, JE Towne - Cytokine, 2022 - Elsevier
The IL-36 family of cytokines includes three pro-inflammatory agonists (IL-36α, IL-36β, and
IL-36γ) and a receptor antagonist (IL-36Ra), which bind and signal through a heterodimeric …
IL-36γ) and a receptor antagonist (IL-36Ra), which bind and signal through a heterodimeric …
Role of the IL-23/IL-17 axis in psoriasis and psoriatic arthritis: the clinical importance of its divergence in skin and joints
Psoriasis is a chronic systemic inflammatory disease causing erythematosus and scaly skin
plaques; up to 30% of patients with psoriasis develop Psoriatic Arthritis (PsA), which is …
plaques; up to 30% of patients with psoriasis develop Psoriatic Arthritis (PsA), which is …
[PDF][PDF] Psoriasis and genetics
Theme issue: Psoriasis loci. Despite the complex correlation structure across the MHC due
to extensive linkage disequilibrium (Box 1)(16), HLA-C* 06: 02 is now confidently …
to extensive linkage disequilibrium (Box 1)(16), HLA-C* 06: 02 is now confidently …
Neutrophil extracellular traps promote inflammatory responses in psoriasis via activating epidermal TLR4/IL-36R crosstalk
S Shao, H Fang, E Dang, K Xue, J Zhang, B Li… - Frontiers in …, 2019 - frontiersin.org
Epidermal infiltration of neutrophils is a hallmark of psoriasis, where their activation leads to
release of neutrophil extracellular traps (NETs). The contribution of NETs to psoriasis …
release of neutrophil extracellular traps (NETs). The contribution of NETs to psoriasis …