Cell-based biosensors and their application in biomedicine

Q Liu, C Wu, H Cai, N Hu, J Zhou, P Wang - Chemical reviews, 2014 - ACS Publications
A biosensor is an analytical device that can be used for detecting analytes and combines a
biological component with a physicochemical detecting transducer. In recent years …

Physics of adherent cells

US Schwarz, SA Safran - Reviews of Modern Physics, 2013 - APS
One of the most unique physical features of cell adhesion to external surfaces is the active
generation of mechanical force at the cell-material interface. This includes pulling forces …

Programming multicellular assembly with synthetic cell adhesion molecules

AJ Stevens, AR Harris, J Gerdts, KH Kim, C Trentesaux… - Nature, 2023 - nature.com
Cell adhesion molecules are ubiquitous in multicellular organisms, specifying precise cell–
cell interactions in processes as diverse as tissue development, immune cell trafficking and …

Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization

EE Er, M Valiente, K Ganesh, Y Zou, S Agrawal… - Nature cell …, 2018 - nature.com
Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches.
Here, we show that mechanotransduction signalling triggered by the pericyte-like spreading …

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed

ML Gardel, B Sabass, L Ji, G Danuser… - The Journal of cell …, 2008 - rupress.org
How focal adhesions (FAs) convert retrograde filamentous actin (F-actin) flow into traction
stress on the extracellular matrix to drive cell migration is unknown. Using combined traction …

Inside-out, outside-in, and inside–outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction

B Shen, MK Delaney, X Du - Current opinion in cell biology, 2012 - Elsevier
The integrin family of cell adhesion receptors mediates bi-directional signaling:'inside-
out'signaling activates the ligand binding function of integrins and 'outside-in'signaling …

Quantitative reflection interference contrast microscopy (RICM) in soft matter and cell adhesion

L Limozin, K Sengupta - ChemPhysChem, 2009 - Wiley Online Library
Adhesion can be quantified by measuring the distance between the interacting surfaces.
Reflection interference contrast microscopy (RICM), with its ability to measure inter‐surface …

The role of filopodia in the recognition of nanotopographies

J Albuschies, V Vogel - Scientific reports, 2013 - nature.com
Substrate-exploring functions of filopodia were previously suggested based on cell studies
on flat surfaces, but their role in topography sensing especially within nanofibrillar …

Multivalent flexible nanogels exhibit broad-spectrum antiviral activity by blocking virus entry

P Dey, T Bergmann, JL Cuellar-Camacho, S Ehrmann… - ACS …, 2018 - ACS Publications
The entry process of viruses into host cells is complex and involves stable but transient
multivalent interactions with different cell surface receptors. The initial contact of several …

Cell crawling mediates collective cell migration to close undamaged epithelial gaps

E Anon, X Serra-Picamal, P Hersen… - Proceedings of the …, 2012 - National Acad Sciences
Fundamental biological processes such as morphogenesis and wound healing involve the
closure of epithelial gaps. Epithelial gap closure is commonly attributed either to the purse …