Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

Variation in the mitochondrial DNA (mtDNA) sequence is common in certain tumours. Two
classes of cancer mtDNA variants can be identified: de novo mutations that act as 'inducers' …

There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …

Mitochondrial diseases are a group of genetic disorders that are characterized by defects in
oxidative phosphorylation and caused by mutations in genes in the nuclear DNA (nDNA) …

REVERSE is a randomized, double-masked, sham-controlled, multicenter, phase 3 clinical
trial that evaluated the efficacy of a single intravitreal injection of rAAV2/2-ND4 in subjects …

Mitochondria were first postulated to contribute to aging more than 40 years ago. During the
following decades, multiple lines of evidence in model organisms and humans showed that …

Mitochondria are subject to unique genetic control by both nuclear DNA and their own
genome, mitochondrial DNA (mtDNA), of which each mitochondrion contains multiple …

Objective Mitochondria are multifunctional life-sustaining organelles that represent a
potential intersection point between psychosocial experiences and biological stress …

Mitochondrial disease associated with the pathogenic m. 3243A> G variant is a common,
clinically heterogeneous, neurogenetic disorder. Using multiple linear regression and linear …

Dysfunctions in mitochondrial dynamics and metabolism are common pathological
processes associated with Parkinson's disease (PD). It was recently shown that an inherited …