The role of oestrogens in male reproductive tract physiology has for a long time been a
subject of debate. The testis produces significant amounts of oestrogenic hormones, via …

The cytochrome P450 aromatase (P450arom) is the terminal enzyme responsible for the
irreversible transformation of androgens into oestrogens and is present in the endoplasmic …

The distribution of active mitochondria during pig oocyte maturation, fertilization and early
embryo development in vitro was revealed by using MitoTracker Green staining and …

The tamoxifen-inducible Cre system is a popular transgenic method for controlling the
induction of recombination by Cre at a specific time and in a specific cell type. However …

Estrogen, through its receptors, regulates various aspects of spermatogenesis and male
fertility. To understand the roles of estrogen receptors (ERα and ERβ) in male fertility, we …

Gonadal steroids and FSH are key regulators of Sertoli cell function. N-Cadherin (N-cad) is a
calcium-dependent cell adhesion molecule that mediates Sertoli cell-germ cell interactions …

Testosterone is considered the primary sex steroids in man and its metabolite, 5α-
dihydrotestosterone (DHT), is recognized as the primary hormone that regulates epididymal …

The dose-related effects of estradiol 17-β at the doses 0.1 μg, 10 μg, 100 μg, 200 μg, 300 μg,
400 μg, 1000 μg/kg/day were determined on sperm motility, potency, fertility parameters …

The 1CH (International Conference on Harmonization of Technical Requirements for
Registration of Pharmaceuticals for Human Use) Guideline for Detection of Toxicity to …

There are always more evidences indicating that 17β‐estradiol (E2) is necessary for normal
male fertility. We have used a nonmammalian vertebrate model (the lizard Podarcis s …