Antibiotic treatment of biofilm infections

O Ciofu, E Rojo‐Molinero, MD Macià, A Oliver - Apmis, 2017 - Wiley Online Library
Bacterial biofilms are associated with a wide range of infections, from those related to
exogenous devices, such as catheters or prosthetic joints, to chronic tissue infections such …

Bronchiectasis in children: diagnosis and treatment

AB Chang, A Bush, K Grimwood - The lancet, 2018 - thelancet.com
Bronchiectasis is conventionally defined as irreversible dilatation of the bronchial tree.
Bronchiectasis unrelated to cystic fibrosis is an increasingly appreciated cause of chronic …

European Respiratory Society guidelines for the management of adult bronchiectasis

E Polverino, PC Goeminne… - European …, 2017 - Eur Respiratory Soc
Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent
exacerbations in many patients. There have been no previous international guidelines. The …

Bronchiectasis

JD Chalmers, AB Chang, SH Chotirmall… - Nature reviews Disease …, 2018 - nature.com
Bronchiectasis refers to abnormal dilatation of the bronchi. Airway dilatation can lead to
failure of mucus clearance and increased risk of infection. Pathophysiological mechanisms …

Diagnosis, monitoring, and treatment of primary ciliary dyskinesia: PCD foundation consensus recommendations based on state of the art review

AJ Shapiro, MA Zariwala, T Ferkol… - Pediatric …, 2016 - Wiley Online Library
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous, rare lung disease resulting
in chronic oto‐sino‐pulmonary disease in both children and adults. Many physicians …

Characterization of the “frequent exacerbator phenotype” in bronchiectasis

JD Chalmers, S Aliberti, A Filonenko… - American journal of …, 2018 - atsjournals.org
Rationale: Exacerbations are key events in the natural history of bronchiectasis, but clinical
predictors and outcomes of patients with frequently exacerbating disease are not well …

Inhaled liposomal ciprofloxacin in patients with non-cystic fibrosis bronchiectasis and chronic lung infection with Pseudomonas aeruginosa (ORBIT-3 and ORBIT-4) …

CS Haworth, D Bilton, JD Chalmers… - The lancet Respiratory …, 2019 - thelancet.com
Background In patients with non-cystic fibrosis bronchiectasis, lung infection with
Pseudomonas aeruginosa is associated with frequent pulmonary exacerbations and …

Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis

JD Chalmers, W Boersma, M Lonergan… - The lancet Respiratory …, 2019 - thelancet.com
Background Bronchiectasis guidelines recommend long-term macrolide treatment for
patients with three or more exacerbations per year without Pseudomonas aeruginosa …

Spanish guidelines on treatment of bronchiectasis in adults

MÁ Martínez-García, L Máiz, C Olveira… - Archivos de …, 2018 - Elsevier
Abstract In 2008, the Spanish Society of Pulmonology (SEPAR) published the first
guidelines in the world on the diagnosis and treatment of bronchiectasis. Almost 10 years …

The efficacy and safety of inhaled antibiotics for the treatment of bronchiectasis in adults: a systematic review and meta-analysis

IF Laska, ML Crichton, A Shoemark… - The lancet respiratory …, 2019 - thelancet.com
Background Although use of inhaled antibiotics is the standard of care in cystic fibrosis,
there is insufficient evidence to support use of inhaled antibiotics in patients with …