Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

The delayed and prolonged postmitotic maturation of human neurons, compared with
neurons from other species, may contribute to human-specific cognitive abilities and …

The intimate relationship between the epithelium and immune system is crucial for
maintaining tissue homeostasis, with perturbations therein linked to autoimmune disease …

Evolutionary changes in human brain structure and function have enabled our specialized
cognitive abilities. How these changes have come about genetically and functionally has …

Human-specific genes are potential drivers of brain evolution. Among them, SRGAP2C has
contributed to the emergence of features characterizing human cortical synapses, including …

Simple Summary Alzheimer's disease (AD) is a progressive, age-related neurodegenerative
disorder representing the most common cause of senile dementia and neurological …

Neocortex expansion during evolution is linked to higher numbers of neurons, which are
thought to result from increased proliferative capacity and neurogenic potential of basal …

Advances in sequencing technologies have enabled the comparison of high-quality
genomes of diverse primate species, revealing vast amounts of divergence due to structural …

Complex structural variations (cxSVs) are often overlooked in genome analyses due to
detection challenges. We developed ARC-SV, a probabilistic and machine-learning-based …

Although solutions based on artificial and computational intelligence have made life easier,
the fast development of technology also raises questions about near future and log term …