The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

The recombination between immunoglobulin (IG) gene segments determines an individual's
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …

Species interactions drive evolution while evolution shapes these interactions. The resulting
eco-evolutionary dynamics and their repeatability depend on how adaptive mutations …

Convergent evolution in the genomics era: new insights and directions | Philosophical
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Natural selection can only operate on available genetic variation. Thus, determining the
probability of accessing different sequence variants from a starting sequence can help …

Evolutionary adaptation often occurs by the fixation of beneficial mutations. This mode of
adaptation can be characterized quantitatively by a spectrum of adaptive substitutions, ie, a …

Predicting evolutionary outcomes is an important research goal in a diversity of contexts.
The focus of evolutionary forecasting is usually on adaptive processes, and efforts to …

Mutations with large fitness benefits and mutations occurring at high rates may both cause
parallel evolution, but their contribution is predicted to depend on population size. Moreover …

Biased mutation spectra are pervasive, with wide variation in the magnitude of mutational
biases that influence genome evolution and adaptation. How do such diverse biases …

Evolutionary biologists have thought about the role of genetic variation during adaptation for
a very long time—before we understood the organization of the genetic code, the …