Little fish, big data: zebrafish as a model for cardiovascular and metabolic disease
The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …
emergence of systems approaches in biology promises new therapies, faster and cheaper …
Contemporary Transposon Tools: A Review and Guide through Mechanisms and Applications of Slee** Beauty, piggyBac and Tol2 for Genome Engineering
N Sandoval-Villegas, W Nurieva, M Amberger… - International journal of …, 2021 - mdpi.com
Transposons are mobile genetic elements evolved to execute highly efficient integration of
their genes into the genomes of their host cells. These natural DNA transfer vehicles have …
their genes into the genomes of their host cells. These natural DNA transfer vehicles have …
Comparative analysis of transposable element vector systems in human cells
I Grabundzija, M Irgang, L Mátés, E Belay, J Matrai… - Molecular therapy, 2010 - cell.com
Transposon-based gene vectors have become indispensable tools in vertebrate genetics for
applications ranging from insertional mutagenesis and transgenesis in model species to …
applications ranging from insertional mutagenesis and transgenesis in model species to …
TIR-Learner, a new ensemble method for TIR transposable element annotation, provides evidence for abundant new transposable elements in the maize genome
Transposable elements (TEs) make up a large and rapidly evolving proportion of plant
genomes. Among Class II DNA TEs, TIR elements are flanked by characteristic terminal …
genomes. Among Class II DNA TEs, TIR elements are flanked by characteristic terminal …
Efficient genetic modification and germ-line transmission of primordial germ cells using piggyBac and Tol2 transposons
J Macdonald, L Taylor, A Sherman… - Proceedings of the …, 2012 - National Acad Sciences
The derivation of germ-line competent avian primordial germ cells establishes a cell-based
model system for the investigation of germ cell differentiation and the production of …
model system for the investigation of germ cell differentiation and the production of …
The expanding universe of transposon technologies for gene and cell engineering
Transposable elements can be viewed as natural DNA transfer vehicles that, similar to
integrating viruses, are capable of efficient genomic insertion. The mobility of class II …
integrating viruses, are capable of efficient genomic insertion. The mobility of class II …
Preclinical and clinical advances in transposon-based gene therapy
Transposons derived from Slee** Beauty (SB), piggyBac (PB), or Tol2 typically require
cotransfection of transposon DNA with a transposase either as an expression plasmid or …
cotransfection of transposon DNA with a transposase either as an expression plasmid or …
Whole Genome Resequencing Reveals Natural Target Site Preferences of Transposable Elements in Drosophila melanogaster
Transposable elements are mobile DNA sequences that integrate into host genomes using
diverse mechanisms with varying degrees of target site specificity. While the target site …
diverse mechanisms with varying degrees of target site specificity. While the target site …
Transposons as tools for functional genomics in vertebrate models
Genetic tools and mutagenesis strategies based on transposable elements are currently
under development with a vision to link primary DNA sequence information to gene …
under development with a vision to link primary DNA sequence information to gene …
[HTML][HTML] Transposons: moving forward from preclinical studies to clinical trials
K ChuahMarinee - Human gene therapy, 2017 - liebertpub.com
Transposons have emerged as promising vectors for gene therapy that can potentially
overcome some of the limitations of commonly used viral vectors. Transposons stably …
overcome some of the limitations of commonly used viral vectors. Transposons stably …