Increased TRPV4 channel expression enhances and impairs blood vessel function in hypertension

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[HTML][HTML] Stay connected: The myoendothelial junction proteins in vascular function and dysfunction

G Querio, F Geddo, S Antoniotti, S Femmino… - Vascular …, 2025 - Elsevier
The appropriate regulation of peripheral vascular tone is crucial for maintaining tissue
perfusion. Myoendothelial junctions (MEJs), specialized connections between endothelial …
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Endothelial Cell TRPV4 Channels Turn to the Dark Side During Hypertension

A Mata-Daboin, JH Jaggar - Hypertension, 2025 - ahajournals.org
In this issue of Hypertension, Zhang et al1 investigated the regulation of intracellular calcium
(Ca2+) signaling in endothelial cells and vascular reactivity in flat-mounted (en face) arteries …
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