Biosynthetic pathway and metabolic engineering of succinic acid

X Liu, G Zhao, S Sun, C Fan, X Feng… - … in Bioengineering and …, 2022 - frontiersin.org
Succinic acid, a dicarboxylic acid produced as an intermediate of the tricarboxylic acid (TCA)
cycle, is one of the most important platform chemicals for the production of various high …

Recent advances, challenges and metabolic engineering strategies in the biosynthesis of 3‐hydroxypropionic acid

B Liang, G Sun, X Zhang, Q Nie… - Biotechnology and …, 2022 - Wiley Online Library
As an attractive and valuable platform chemical, 3‐hydroxypropionic acid (3‐HP) can be
used to produce a variety of industrially important commodity chemicals and biodegradable …

An acid-tolerance response system protecting exponentially growing Escherichia coli

Y Xu, Z Zhao, W Tong, Y Ding, B Liu, Y Shi… - Nature …, 2020 - nature.com
The ability to grow at moderate acidic conditions (pH 4.0–5.0) is important to Escherichia coli
colonization of the host's intestine. Several regulatory systems are known to control acid …

Hyperproduction of 3-hydroxypropionate by Halomonas bluephagenesis

XR Jiang, X Yan, LP Yu, XY Liu, GQ Chen - Nature communications, 2021 - nature.com
Hydroxypropionic acid (3HP), an important three carbon (C3) chemical, is designated as
one of the top platform chemicals with an urgent need for improved industrial production …

Sustainable production of acrylic acid via 3-hydroxypropionic acid from lignocellulosic biomass

SS Bhagwat, Y Li, YR Cortés-Peña… - ACS Sustainable …, 2021 - ACS Publications
Lignocellulosic biomass is a promising renewable feedstock for the sustainable
manufacturing of biofuels and bioproducts. Among emerging bioproducts, 3 …

Coupling cell growth and biochemical pathway induction in Saccharomyces cerevisiae for production of (+)-valencene and its chemical conversion to (+)-nootkatone

Z Ye, Y Huang, B Shi, Z **ang, Z Tian, M Huang… - Metabolic …, 2022 - Elsevier
Nootkatone is a valuable, functional sesquiterpene that is widely used in food, cosmetics,
pharmaceutical, agriculture, and other fields. However, only traces of it accumulate in plants …

Efficient bioproduction of 3-hydroxypropionic acid from methanol by a synthetic yeast cell factory

X Wu, P Cai, L Gao, Y Li, L Yao… - … Sustainable Chemistry & …, 2023 - ACS Publications
Methanol is an ideal feedstock for bio-manufacturing chemicals without the dependence of
sugars and the competition of arable lands. We here engineered an industrial yeast Pichia …

Metabolic engineering of Corynebacterium glutamicum for the production of 3-hydroxypropionic acid from glucose and xylose

Z Chen, J Huang, Y Wu, W Wu, Y Zhang, D Liu - Metabolic Engineering, 2017 - Elsevier
Hydroxypropionic acid (3-HP) is a promising platform chemical which can be used for the
production of various value-added chemicals. In this study, Corynebacterium glutamicum …

Overproduction of 3-hydroxypropionate in a super yeast chassis

W Yu, X Cao, J Gao, YJ Zhou - Bioresource technology, 2022 - Elsevier
Hydroxypropionate (3-HP) is a platform chemical for production of acrylic acid, acrylamide
and biodegradable polymers. Several microbial cell factories have been constructed for …

Engineering Rhodosporidium toruloides for production of 3-hydroxypropionic acid from lignocellulosic hydrolysate

D Liu, HJ Hwang, PB Otoupal, GM Geiselman… - Metabolic …, 2023 - Elsevier
Microbial production of valuable bioproducts is a promising route towards green and
sustainable manufacturing. The oleaginous yeast, Rhodosporidium toruloides, has emerged …