The role of PKC-MAPK signalling pathways in the development of hyperglycemia-induced cardiovascular complications

FF Jubaidi, S Zainalabidin, IS Taib… - International Journal of …, 2022 - mdpi.com
Cardiovascular disease is the most common cause of death among diabetic patients
worldwide. Hence, cardiovascular wellbeing in diabetic patients requires utmost importance …

Protective role of Nrf2 in renal disease

M Guerrero-Hue, S Rayego-Mateos… - Antioxidants, 2020 - mdpi.com
Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted
to become by 2040 the fifth global cause of death. CKD is characterized by increased …

Effect of redox modulating NRF2 activators on chronic kidney disease

B Choi, KS Kang, MK Kwak - Molecules, 2014 - mdpi.com
Chronic kidney disease (CKD) is featured by a progressive decline of kidney function and is
mainly caused by chronic diseases such as diabetes mellitus and hypertension. CKD is a …

Antidiabetic properties of curcumin II: evidence from in vivo studies

DJ Den Hartogh, A Gabriel, E Tsiani - Nutrients, 2019 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a growing metabolic disease characterized by insulin
resistance and hyperglycemia. Current preventative and treatment approaches to insulin …

The interplay of renin‐angiotensin system and toll‐like receptor 4 in the inflammation of diabetic nephropathy

Q Feng, D Liu, Y Lu, Z Liu - Journal of Immunology Research, 2020 - Wiley Online Library
Diabetic nephropathy (DN) is one of the most serious chronic kidney diseases and the major
cause of end‐stage renal failure worldwide. The underlying mechanisms of DN are complex …

Therapeutic effects of curcumin derivatives against obesity and associated metabolic complications: a review of in vitro and in vivo studies

MT Moetlediwa, R Ramashia, C Pheiffer… - International Journal of …, 2023 - mdpi.com
Obesity is a major cause of morbidity and mortality globally, increasing the risk for chronic
diseases. Thus, the need to identify more effective anti-obesity agents has spurred …

Anti-inflammatory effects of novel curcumin analogs in experimental acute lung injury

Y Zhang, D Liang, L Dong, X Ge, F Xu, W Chen… - Respiratory …, 2015 - Springer
Background Acute lung injury (ALI) and its most severe form acute respiratory distress
syndrome (ARDS) have been the leading cause of morbidity and mortality in intensive care …

[HTML][HTML] An examination of the protective effects and molecular mechanisms of curcumin, a polyphenol curcuminoid in diabetic nephropathy

X Zhu, X Xu, C Du, Y Su, L Yin, X Tan, H Liu… - Biomedicine & …, 2022 - Elsevier
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease and is an
enormous burden on both patients and society. There is an urgent need for effective …

Overview of curcumin and piperine effects on glucose metabolism: The case of an insulinoma patient's loss of consciousness

S Servida, E Panzeri, L Tomaino, G Marfia… - International Journal of …, 2023 - mdpi.com
The hypoglycemic properties of curcumin supplements in therapeutic doses are well-known
and may represent a useful tool for the treatment of chronic diseases such as metabolic …

Experimental evidence for curcumin and its analogs for management of diabetes mellitus and its associated complications

S Rivera-Mancía, MC Lozada-García… - European Journal of …, 2015 - Elsevier
Diabetes mellitus is a serious world health problem and one of the most studied diseases; a
major concern about its treatment is that β-cell mass and functionality is hard to restore. In …