Molecular mechanisms and applications of N-acyl homoserine lactone-mediated quorum sensing in bacteria
Microbial biodiversity includes biotic and abiotic components that support all life forms by
adapting to environmental conditions. Climate change, pollution, human activity, and natural …
adapting to environmental conditions. Climate change, pollution, human activity, and natural …
Antibiotic adjuvants: Synergistic tool to combat multi-drug resistant pathogens
The rise of multi-drug resistant (MDR) pathogens poses a significant challenge to the field of
infectious disease treatment. To overcome this problem, novel strategies are being explored …
infectious disease treatment. To overcome this problem, novel strategies are being explored …
Recovering the susceptibility of antibiotic-resistant bacteria using photooxidative damage
Multidrug-resistant bacteria are one of the most serious threats to infection control. Few new
antibiotics have been developed; however, the lack of an effective new mechanism of their …
antibiotics have been developed; however, the lack of an effective new mechanism of their …
Design and synthesis of novel benzimidazole derivatives as potential Pseudomonas aeruginosa anti-biofilm agents inhibiting LasR: Evidence from comprehensive …
Quorum sensing (QS) inhibition is one of the potential methods to target bacterial infection.
In this study, comprehensive molecular dynamics simulation (MDS) experiments were …
In this study, comprehensive molecular dynamics simulation (MDS) experiments were …
A novel brominated chalcone derivative as a promising multi-target inhibitor against multidrug-resistant Listeria monocytogenes
Foodborne pathogens continue to challenge public health due to their ability to cause
severe illness and their increasing resistance to current antimicrobial treatments. Listeria …
severe illness and their increasing resistance to current antimicrobial treatments. Listeria …
Design, synthesis, and computational analysis (molecular docking, DFT, MEP, RDG, ELF) of diazepine and oxazepine sulfonamides: Biological evaluation for in vitro …
We report the synthesis and extensive characterization of Diazepane and Oxazepane
derivatives, followed by their biological evaluation. These compounds were assessed for in …
derivatives, followed by their biological evaluation. These compounds were assessed for in …
Synthesis, antimicrobial, DNA binding, and computational studies of some bis-and poly (4-methyl-2H-chromen-2-one) derivatives
The research focused on studying how 7-hydroxy-4-methyl-2H-chromen-2-one can be used
as a building material for new bis-and poly (coumarins) through alkylation with related bis …
as a building material for new bis-and poly (coumarins) through alkylation with related bis …
Opportunities and challenges of microbial siderophores in the medical field
Siderophores are low-molecular-weight secondary metabolites that function as iron
chelators. Under iron-deficiency conditions, they are produced by a wide variety of microbes …
chelators. Under iron-deficiency conditions, they are produced by a wide variety of microbes …
Combatting antimicrobial resistance via the cysteine biosynthesis pathway in bacterial pathogens
JL Hicks, KEA Oldham, J McGarvie… - Bioscience …, 2022 - portlandpress.com
Antibiotics are the cornerstone of modern medicine and agriculture, and rising antibiotic
resistance is one the biggest threats to global health and food security. Identifying new and …
resistance is one the biggest threats to global health and food security. Identifying new and …
Novel quinoline‐based derivatives as the PqsR inhibitor against Pseudomonas aeruginosa PAO1
XH Huang, MT She, YH Zhang, YF Liu… - Journal of applied …, 2022 - academic.oup.com
Aims The emerging of drug resistant Pseudomonas aeruginosa is a critical challenge and
renders an urgent action to discover innovative antimicrobial interventions. One of these …
renders an urgent action to discover innovative antimicrobial interventions. One of these …