Chemokines are pivotal regulators of cell migration during continuous immune surveillance,
inflammation, homeostasis, and development. Chemokine binding to their 7-transmembrane …

More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that
play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling …

G protein-coupled receptors (GPCRs) mediate diverse signaling in part through interaction
with arrestins, whose binding promotes receptor internalization and signaling through G …

Carvedilol is among the most effective β-blockers for improving survival after myocardial
infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are …

G Protein-coupled receptors (GPCRs) constitute the largest family of cell surface receptors
and drug targets. GPCR signalling and desensitization is critically regulated by β-arrestins …

Binding mechanism of arrestin requires photoactivation and phosphorylation of the receptor
protein rhodopsin, where the receptor bound phosphate groups cause displacement of the …

Corona virus spike protein S is a large homo-trimeric protein anchored in the membrane of
the virion particle. Protein S binds to angiotensin-converting-enzyme 2, ACE2, of the host …

G protein-coupled receptors (GPCRs) are a major membrane receptor family with important
physiological and pathological functions. In the classical signaling pathway, ligand-activated …

Arrestins desensitize G protein-coupled receptors (GPCRs) and act as mediators of
signalling. Here we investigated the interactions of arrestin-1 with two functionally distinct …

Atypical chemokine receptors (ACKRs) have emerged as a subfamily of chemokine
receptors regulating the local bioavailability of their ligands through scavenging …