Organ-on-chip systems are promising new in vitro research tools in medical,
pharmaceutical, and biological research. Their main benefit, compared to standard cell …

Bioelectronics have made strides in improving clinical diagnostics and precision medicine.
The potential of bioelectronics for bidirectional interfacing with biology through continuous …

Kidney toxicity is one of the most frequent adverse events reported during drug
development. The lack of accurate predictive cell culture models and the unreliability of …

Improved model systems to predict drug efficacy, interactions, and drug-induced kidney
injury (DIKI) are crucially needed in drug development. Organ-on-a-chip technology is a …

Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

In polycystic kidney disease (PKD), fluid-filled cysts arise from tubules in kidneys and other
organs. Human kidney organoids can reconstitute PKD cystogenesis in a genetically …

As a full-fidelity simulation of human cells, tissues, organs, and even systems at the
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …

In vitro models of biological tissues are indispensable tools for unraveling human physiology
and pathogenesis. They usually consist of a single layer of a single cell type, which makes …

Trans-epithelial electrical resistance (TEER) measurements are widely used as real-time,
non-destructive, and label-free measurements of epithelial and endothelial barrier function …

Numerous micro-physiological systems have been reported to successfully mimic the organ
microenvironment. However, there are currently only a few systems that focus on real-time …