Pirfenidone: molecular mechanisms and potential clinical applications in lung disease

SM Ruwanpura, BJ Thomas… - American journal of …, 2020 - atsjournals.org
Pirfenidone (PFD) is a pharmacological compound with therapeutic efficacy in idiopathic
pulmonary fibrosis. It has been chiefly characterized as an antifibrotic agent, although it was …

Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits

AG Mathioudakis, W Janssens, P Sivapalan… - Thorax, 2020 - thorax.bmj.com
Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with a
significant mortality, health and economic burden. Their diagnosis, assessment and …

Predicting patient decompensation from continuous physiologic monitoring in the emergency department

S Sundrani, J Chen, BT **, ZSH Abad… - NPJ Digital …, 2023 - nature.com
Anticipation of clinical decompensation is essential for effective emergency and critical care.
In this study, we develop a multimodal machine learning approach to predict the onset of …

Influenza vaccine for chronic obstructive pulmonary disease (COPD)

Z Kopsaftis, R Wood‐Baker… - Cochrane Database of …, 2018 - cochranelibrary.com
Background Influenza vaccinations are currently recommended in the care of people with
COPD, but these recommendations are based largely on evidence from observational …

Fatigue as the chief complaint: epidemiology, causes, diagnosis, and treatment

P Maisel, E Baum… - Deutsches Ärzteblatt …, 2021 - pmc.ncbi.nlm.nih.gov
Background Fatigue is a main or secondary reason for 10–20% of all consultations with a
primary care physician. Methods This review is based on pertinent publications retrieved by …

COPD and the gut-lung axis: the therapeutic potential of fibre

A Vaughan, ZA Frazer, PM Hansbro… - Journal of thoracic …, 2019 - pmc.ncbi.nlm.nih.gov
Current management strategies for chronic obstructive pulmonary disease (COPD)
incorporate a step-wise, multidisciplinary approach to effectively manage patient symptoms …

COPD‐X Australian guidelines for the diagnosis and management of chronic obstructive pulmonary disease: 2022 update

E Dabscheck, J George, K Hermann… - Medical Journal of …, 2022 - Wiley Online Library
Introduction Chronic obstructive pulmonary disease (COPD) is a treatable and preventable
disease characterised by persistent respiratory symptoms and chronic airflow limitation on …

Chronic obstructive pulmonary disease and lung cancer: underlying pathophysiology and new therapeutic modalities

MS Eapen, PM Hansbro, AK Larsson‑Callerfelt… - Drugs, 2018 - Springer
Chronic obstructive pulmonary disease (COPD) and lung cancer are major lung diseases
affecting millions worldwide. Both diseases have links to cigarette smoking and exert a …

[HTML][HTML] LABA/LAMA as first-line therapy for COPD: a summary of the evidence and guideline recommendations

M Miravitlles, T Kawayama, M Dreher - Journal of clinical medicine, 2022 - mdpi.com
Inhaled bronchodilators (alone or in combination) are the cornerstone of treatment for
symptomatic patients with COPD, either as initial/first-line treatment or for second …