Therapy-related clonal hematopoiesis (t-CH) is defined as clonal hematopoiesis detected in
individuals previously treated with chemotherapy and/or radiation therapy. With the …

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the selective
expansion of hematopoietic stem and progenitor cells (HSPCs) carrying somatic mutations …

Cell cycle checkpoints, oncogene-induced senescence and programmed cell death
represent intrinsic barriers to tumorigenesis. Protein phosphatase magnesium-dependent 1 …

Telomere biology disorders (TBDs), caused by pathogenic germ line variants in telomere-
related genes, present with multiorgan disease and a predisposition to cancer. Clonal …

Pancreatic cancer remains one of the most aggressive and lethal malignancies worldwide,
with a dismal 5-year relative survival rates of only 12%. Therefore, it is urgent to discover the …

Clonal hematopoiesis in children and young adults differs from that occuring in the older
adult population. A variety of stressors drive this phenomenon, sometimes independent of …

BH3 profiling can assess global mitochondrial priming and dependence of leukemic cells on
specific BH3 anti‐apoptotic proteins such as BCL‐2. In acute myeloid leukemia (AML), proof …

The tumor microenvironment (TME) is involved in cancer initiation and progression. With
advances in the TME field, numerous therapeutic approaches, such as antiangiogenic …

Cell death and related signaling pathways are essential during development and in various
physiological and pathological conditions. Post-translational modifications such as …

Therapy-related myeloid neoplasms (t-MN) are characterized by aggressive features and a
dismal prognosis. Recent evidence suggests a higher incidence of t-MN in individuals …