Polyploidy has been hypothesized to be both an evolutionary dead-end and a source for
evolutionary innovation and species diversification. Although polyploid organisms …

Evolvability is the ability of a biological system to produce phenotypic variation that is both
heritable and adaptive. It has long been the subject of anecdotal observations and …

Whole-genome duplications have shaped the genomes of several vertebrate, plant, and
fungal lineages. Earlier studies have focused on establishing when these events occurred …

Gene duplication is a prevalent phenomenon across the tree of life. The processes that lead
to the retention of duplicated genes are not well understood. Functional genomics …

Coronary artery disease (CAD) is the leading form of cardiovascular disease (CVD), which is
the primary cause of mortality worldwide. It is a complex disease with genetic and …

Polyploidy, resulting from whole‐genome duplication (WGD), is ubiquitous in nature and
reportedly associated with extreme environments and biological invasions. However, WGD …

Protein folding both promotes and constrains adaptive evolution. We uncover this surprising
duality in the role of the protein-folding chaperone heat shock protein 90 (Hsp90) in …

Gene duplication is a recurring phenomenon in genome evolution and a major driving force
in the gain of biological functions. Here, we examine the role of gene duplication in the …

Gene duplicates, generated through either whole genome duplication (WGD) or small-scale
duplication (SSD), are prominent in angiosperms and are believed to play an important role …

Evolutionary variations generating phenotypic adaptations and novel taxa resulted from
complex cellular activities altering genome content and expression:(i) Symbiogenetic cell …