An important pathological feature of Alzheimer's disease (AD) is the presence of
extracellular senile plaques in the brain. Senile plaques are composed of aggregations of …

The generation of amyloid β-peptide (Aβ) by enzymatic cleavages of the β-amyloid
precursor protein (APP) has been at the center of Alzheimer's disease (AD) research. While …

Cathepsin B (CTSB) is a powerful lysosomal protease. This review evaluated CTSB gene
knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and …

J. Neurochem.(2012) 120 (Suppl. 1), 9–21. Abstract β‐Amyloid precursor protein (APP) is a
critical factor in the pathogenesis of Alzheimer's disease (AD). APP undergoes post …

The amyloid precursor protein (APP) plays a central role in the pathophysiology of
Alzheimer's disease in large part due to the sequential proteolytic cleavages that result in …

Cysteine proteases continue to provide validated targets for treatment of human diseases. In
neurodegenerative disorders, multiple cysteine proteases provide targets for enzyme …

Alzheimer's disease (AD) may result from the accumulation of amyloid-β (Aβ) peptides in the
brain. The cysteine protease cathepsin B (CatB) is associated with amyloid plaques in AD …

Cathepsin B (CTSB), a lysosomal cysteine protease, plays an important role in human
physiology and pathology. CTSB is associated with various human diseases, and its …

Aging is accompanied by a decline in memory and other brain functions. Physical exercise
may mitigate this decline through the modulation of factors participating in the crosstalk …

Streptococcus pneumoniae meningitis causes brain damage through inflammation-related
pathways whose identity and mechanisms of action are yet unclear. We previously identified …