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Signaling pathways in inflammation and anti-inflammatory therapies
During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …
Coal mine dust lung disease in the modern era
ABSTRACT Coal workers' pneumoconiosis (CWP), as part of the spectrum of coal mine dust
lung disease (CMDLD), is a preventable but incurable lung disease that can be complicated …
lung disease (CMDLD), is a preventable but incurable lung disease that can be complicated …
p16 (Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli
Constitutive p16Ink4a expression, along with senescence-associated β-galactosidase
(SAβG), are commonly accepted biomarkers of senescent cells (SCs). Recent reports …
(SAβG), are commonly accepted biomarkers of senescent cells (SCs). Recent reports …
Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling
Background The FDA-approved small-molecule drug dasatinib is currently used as a
treatment for chronic myeloid leukemia (CML). However, the effects of dasatinib on …
treatment for chronic myeloid leukemia (CML). However, the effects of dasatinib on …
Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence
Acute kidney injury (AKI) is a common clinical problem, and patients who survive AKI have a
high risk of chronic kidney disease (CKD). The mechanism of CKD post‐AKI, characterized …
high risk of chronic kidney disease (CKD). The mechanism of CKD post‐AKI, characterized …
Matrix metalloproteinase: An upcoming therapeutic approach for idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a debilitating condition where excess collagen
deposition occurs in the extracellular matrix. At first sight, it is expected that the level of …
deposition occurs in the extracellular matrix. At first sight, it is expected that the level of …
[HTML][HTML] From basic research to clinical practice: considerations for treatment drugs for Silicosis
R Li, H Kang, S Chen - International Journal of Molecular Sciences, 2023 - mdpi.com
Silicosis, characterized by irreversible pulmonary fibrosis, remains a major global public
health problem. Nowadays, cumulative studies are focusing on elucidating the pathogenesis …
health problem. Nowadays, cumulative studies are focusing on elucidating the pathogenesis …
Cell‐based therapy for silicosis
Silicosis is the most common pneumoconiosis globally, with higher prevalence and
incidence in develo** countries. To date, there is no effective treatment to halt or reverse …
incidence in develo** countries. To date, there is no effective treatment to halt or reverse …
Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice
The uterine fibrosis contributes to gestational outcomes. Collagen deposition in the uterus is
related to uterine aging. Senolytic therapies are an option for reducing health complications …
related to uterine aging. Senolytic therapies are an option for reducing health complications …
[HTML][HTML] A novel pathophysiological classification of silicosis models provides some new insights into the progression of the disease
Silicosis is caused by massive inhalation of silica-based particles, which leads to pulmonary
inflammation, pulmonary fibrosis and lung dysfunction. Currently, the pathophysiological …
inflammation, pulmonary fibrosis and lung dysfunction. Currently, the pathophysiological …