Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the central nervous system
The gene encoding proprotein convertase subtilisin/kexin type 9 (PCSK9) and its protein
product have been widely studied for their role in cholesterol and lipid metabolism. PCSK9 …
product have been widely studied for their role in cholesterol and lipid metabolism. PCSK9 …
Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease
M Abifadel, JP Rabès, M Devillers, A Munnich… - Human …, 2009 - Wiley Online Library
Hypercholesterolemia is one of the major causes of coronary heart disease (CHD). The
genes encoding the low‐density lipoprotein receptor and its ligand apolipoprotein B, have …
genes encoding the low‐density lipoprotein receptor and its ligand apolipoprotein B, have …
The activation and physiological functions of the proprotein convertases
The mammalian secretory proprotein convertases are part of a family of nine serine
proteinases of the subtilisin-type. Seven of them cleave after basic amino acids and are …
proteinases of the subtilisin-type. Seven of them cleave after basic amino acids and are …
Induction of sustained hypercholesterolemia by single adeno-associated virus–mediated gene transfer of mutant hPCSK9
M Roche-Molina, D Sanz-Rosa, FM Cruz… - … , and vascular biology, 2015 - Am Heart Assoc
Objectives—Patients with mutations in the proprotein convertase subtilisin/kexin type 9
(PCSK9) gene have hypercholesterolemia and are at high risk of adverse cardiovascular …
(PCSK9) gene have hypercholesterolemia and are at high risk of adverse cardiovascular …
The genetics of diabetic complications
The rising global prevalence of diabetes mellitus is accompanied by an increasing burden of
morbidity and mortality that is attributable to the complications of chronic hyperglycaemia …
morbidity and mortality that is attributable to the complications of chronic hyperglycaemia …
PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax–caspase9–caspase3 pathway
CY Wu, ZH Tang, L Jiang, XF Li, ZS Jiang… - Molecular and cellular …, 2012 - Springer
This paper investigated the effects of ox-LDL on PCSK9, and the molecular mechanisms of
PCSK9 siRNA-inhibited apoptosis induced by ox-LDL in human umbilical vein endothelial …
PCSK9 siRNA-inhibited apoptosis induced by ox-LDL in human umbilical vein endothelial …
Clinical aspects of PCSK9
Proprotein convertase subtilisin kexin type 9 (PCSK9) is a circulating protein that impairs
LDL clearance by promoting the LDL receptor (LDLR) degradation. PCSK9 has emerged as …
LDL clearance by promoting the LDL receptor (LDLR) degradation. PCSK9 has emerged as …
Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the brain and relevance for neuropsychiatric disorders
EM O'Connell, FW Lohoff - Frontiers in neuroscience, 2020 - frontiersin.org
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has long been studied in the liver due
to its regulation of plasma low-density lipoprotein cholesterol (LDL-C) and its causal role in …
to its regulation of plasma low-density lipoprotein cholesterol (LDL-C) and its causal role in …
[HTML][HTML] Accelerated atherosclerosis development in C57Bl6 mice by overexpressing AAV-mediated PCSK9 and partial carotid ligation
Studying the role of a particular gene in atherosclerosis typically requires a time-consuming
and often difficult process of generating double knockouts or transgenics on ApoE−/− or LDL …
and often difficult process of generating double knockouts or transgenics on ApoE−/− or LDL …
Physiology and role of PCSK9 in vascular disease: Potential impact of localized PCSK9 in vascular wall
Y Guo, B Yan, Y Gui, Z Tang, S Tai… - Journal of cellular …, 2021 - Wiley Online Library
Proprotein convertase subtilisin/kexin type‐9 (PCSK9), a member of the proprotein
convertase family, is an important drug target because of its crucial role in lipid metabolism …
convertase family, is an important drug target because of its crucial role in lipid metabolism …