Summary The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …

Dissimilatory sulphate reduction is the unifying and defining trait of sulphate-reducing
prokaryotes (SRP). In their predominant habitats, sulphate-rich marine sediments, SRP have …

Determining protein levels in each tissue and how they compare with RNA levels is
important for understanding human biology and disease as well as regulatory processes …

Sex differences in brain structure and function are of substantial scientific interest because of
sex-related susceptibility to psychiatric and neurological disorders. Neuroinflammation is a …

An important issue for molecular biology is to establish whether transcript levels of a given
gene can be used as proxies for the corresponding protein levels. Here, we have developed …

Nitric oxide (NO) has important functions in biology and atmospheric chemistry as a toxin,
signaling molecule, ozone depleting agent and the precursor of the greenhouse gas nitrous …

Background Toll-like receptor (TLR) signaling is emerging as an important component of
neurodegeneration. TLR7 senses viral RNA and certain endogenous miRNAs to initiate …

Patients with major depressive disorder have elevated peripheral inflammation; the degree
of this increase correlates with the severity of the disorder. Chronic psychological stress …

This paper reviews methods for detecting proteins based on molecular digitization, ie, the
isolation and detection of single protein molecules or singulated ensembles of protein …

A limitation of conventional bulk-tissue proteome studies in amyotrophic lateral sclerosis
(ALS) is the confounding of motor neuron (MN) signals by admixed non-MN proteins. Here …