Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein's stability. These regions …

Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Protein ubiquitination is a dynamic multifaceted post-translational modification involved in
nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid …

Protein ubiquitination is one of the most powerful posttranslational modifications of proteins,
as it regulates a plethora of cellular processes in distinct manners. Simple …

Ubiquitylation is essential for signal transduction as well as cell division and differentiation in
all eukaryotes. Substrate modifications range from a single ubiquitin molecule to complex …

Production of reactive oxygen species (ROS) is critical for successful activation of immune
responses against pathogen infection. The plant NADPH oxidase RBOHD is a primary …

Protein phosphorylation is a major regulator of protein function and biological outcomes.
This was first recognized through functional biochemical experiments, and in the past …

Regulatory protein phosphorylation controls normal and pathophysiological signaling in
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …

Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …

Post-translational modifications (PTMs) are at the heart of many cellular signaling events.
Apart from a single regulatory PTM, there are also PTMs that function in orchestrated …