Accumulating evidence points to the causal role of triglyceride-rich lipoproteins and their
cholesterol-enriched remnants in atherogenesis. Genetic studies in particular have not only …

Multifactorial chylomicronemia syndrome (MCS or type V hyperlipoproteinemia) is the most
frequent cause of severe hypertriglyceridemia and is associated with an increased risk of …

Lipolysis of triglyceride-rich lipoproteins by LpL is a central event in lipid metabolism,
releasing fatty acids for uptake by tissues and generating low-density lipoprotein and …

Severe hypertriglyceridaemia is associated with pancreatitis and chronic pancreatitis-
induced diabetes. Familial chylomicronaemia syndrome (FCS) is a rare autosomal recessive …

Abstract Purpose of Review Hypertriglyceridemia (HTG) is common and is a significant
contributor to atherosclerosis and pancreatitis risk. Specific HTG treatments have had …

Non-alcoholic fatty liver disease (NAFLD) is frequent in patients with features of the
metabolic syndrome (MetS), obesity, or type 2 diabetes. Lipoprotein lipase (LPL) is the main …

We have reviewed the genetic basis of chylomicronaemia, the difference between
monogenic and polygenic hypertriglyceridaemia, its effects on pancreatic, cardiovascular …

Background Familial hypercholesterolemia (FH) may arise from deleterious monogenic
variants in FH‐causing genes as well as from a polygenic cause. We evaluated the …

Objective: Genetic determinants of severe hypertriglyceridemia include both common
variants with small effects (assessed using polygenic risk scores) plus heterozygous and …

Nucleic acid-based therapies are being rapidly developed for prevention and management
of cardiovascular diseases (CVD). Remarkable advancements have been achieved in the …