Cutaneous fibrosis results from suboptimal wound healing following significant tissue injury
such as severe burns, trauma, and major surgeries. Pathologic skin fibrosis results in scars …

Differences in toxic effects of contaminants among human cells are essential for evaluating
their health risks to humans. In this study, non-targeted metabolomics of multiple human cell …

Lung fibroblasts participate in the pathogenesis of respiratory diseases, including lung
cancer and pulmonary fibrosis. Although fibroblasts are ubiquitous constituents of various …

Subepithelial fibrosis occurs in a subset of eosinophilic esophagitis (EoE) patients and is
associated with esophageal stricture. While mechanisms driving EoE fibrosis remain …

Fibroblasts provide a structural framework for multiple organs and are essential for wound
repair and fibrotic processes. Here, we demonstrate functional roles of FOXL1 (forkhead box …

Soft polymers have emerged as a vital type of material adopted in biomedical engineering to
perform various biomechanical characterisations such as sensing cellular forces. Distinct …

The inflammatory reaction influences the deposition of collagen within wound granulation
tissue. The aim of the present study is to determine whether histamine acting directly on …

Histamine is an inflammatory mediator that can be released from mast cells to induce airway
remodeling and cause persistent airflow limitation in asthma. In addition to stimulating …

Cell contraction force plays an important role in wound healing, inflammation, angiogenesis
and metastasis. This study describes a novel method to quantify single cell contraction force …

Background: Bronchial asthma is a chronic airway disease characterized by eosinophilic
airway inflammation. Lung fibroblasts activated by IL-13 serve as important sources of …