Marine indole alkaloids comprise a large and steadily growing group of secondary
metabolites. Their diverse biological activities make many compounds of this class attractive …

Cross-coupling reactions are powerful synthetic tools for the formation of remarkable
building blocks of many naturally occurring molecules, polymers and biologically active …

Chronic inflammation is triggered by numerous diseases such as osteoarthritis, Crohn's
disease and cancer. The control of the pro-inflammatory process can prevent, mitigate …

To combat the ineffectiveness of currently available pharmaceutical medications, caused by
the emergence of increasingly resistant bacterial and fungal strains, novel antibacterial and …

Tellurium compounds have been described as potential leishmanicides, bearing promising
leishmanicidal and antimalarial effects. Therefore, the present study investigated the …

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) disease is a global rapidly
spreading virus showing very high rates of complications and mortality. Till now, there is no …

Background: The need to develop novel antimicrobial agents is apparent as infectious
diseases are increasing and resistance is rapidly develo** against the drugs used in the …

Marine actinomycetes are an important source of antibiotics, but many of them are yet to be
explored in terms of taxonomy, ecology, and functional activity. In this study, two marine …

Nitrogen heterocycles are valuable structural elements in the molecules of antibacterial
drugs approved and used to treat bacterial infections. Pyrrole is a five-atom heterocycle …

The first total synthesis of the antimicrobial natural product lynamicin D has been developed
using a Suzuki coupling to construct the bisindole pyrrole skeleton. An evaluation of the …