A> G substitutions on a heavy chain of mitochondrial genome marks an increased level of aerobic metabolism in warm versus cold vertebrates

AG Mikhailova, D Iliushchenko, V Shamansky… - BioRxiv, 2020 - biorxiv.org
Mutational spectrum of the mitochondrial genome (mtDNA) fluctuates between species,
however, factors responsible for this variation are mainly unknown. Recently, we …

[PDF][PDF] A mitochondrial mutational signature of temperature and longevity in ectothermic and endothermic vertebrates

AG Mikhailova, V Shamansky, AA Mikhailova… - bioRxiv, 2020 - academia.edu
Mitochondrial mutational signature is very conserved and low deviations between species
have been associated with longevity. By reconstructing species-specific mtDNA mutational …

Risk of mitochondrial deletions is affected by the global secondary structure of the human mitochondrial genome

V Shamanskiy, AA Mikhailova, K Ushakova… - BioRxiv, 2019 - biorxiv.org
Aging is often associated with clonal expansion of somatic mitochondrial deletions, while
their origin is still poorly understood. Deletions are often flanked by direct nucleotide …

Конференция «Ломоносов 2020»

С Генетика, ЕД Кулаева - sciences, 2019 - lomonosov-msu.ru
Atrx-это ген, кодирующий хроматин-ремоделирующий белок, который участвует в
образовании гетерохроматина в области теломер. Определение точных связей …