Hepatocellular carcinoma (HCC) is a leading lethal malignancy worldwide. However, the
molecular mechanisms underlying liver carcinogenesis remain poorly understood. Over the …

Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

The Enc yclopedia of D NA E lements (ENCODE) Data Coordinating Center has developed
the ENCODE Portal database and website as the source for the data and metadata …

Transcription factor (TF) DNA sequence preferences direct their regulatory activity, but are
currently known for only∼ 1% of eukaryotic TFs. Broadly sampling DNA-binding domain …

Current methods for annotating and interpreting human genetic variation tend to exploit a
single information type (for example, conservation) and/or are restricted in scope (for …

Background System-wide profiling of genes and proteins in mammalian cells produce lists of
differentially expressed genes/proteins that need to be further analyzed for their collective …

Abstract The Encyclopedia of DNA Elements (ENCODE) Project is in its third phase of
creating a comprehensive catalog of functional elements in the human genome. This phase …

Hepatocellular carcinoma (HCC) is the most frequent subtype of primary liver cancer and
one of the leading causes of cancer-related death worldwide. However, the molecular …

We present a DNA library preparation method that has allowed us to reconstruct a high-
coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The …

Chromatin immunoprecipitation (ChIP) followed by high-throughput DNA sequencing (ChIP-
seq) has become a valuable and widely used approach for map** the genomic location of …