Phage lysins for intestinal microbiome modulation: current challenges and enabling techniques

I Pottie, R Vázquez Fernández, T Van de Wiele… - Gut …, 2024 - Taylor & Francis
The importance of the microbiota in the intestinal tract for human health has been
increasingly recognized. In this perspective, microbiome modulation, a targeted alteration of …

[HTML][HTML] Clostridioides difficile and gut microbiota: from colonization to infection and treatment

P Spigaglia - Pathogens, 2024 - mdpi.com
Clostridioides difficile is the main causative agent of antibiotic-associated diarrhea (AAD) in
hospitals in the developed world. Both infected patients and asymptomatic colonized …

Meta-analysis of 16S rRNA microbial data identified alterations of the gut microbiota in COVID-19 patients during the acute and recovery phases

X Cheng, Y Zhang, Y Li, Q Wu, J Wu, SK Park, C Guo… - BMC microbiology, 2022 - Springer
Background Dozens of studies have demonstrated gut dysbiosis in COVID-19 patients
during the acute and recovery phases. However, a consensus on the specific COVID-19 …

Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments

TS Rasmussen, X Mao, S Forster, SB Larsen… - Microbiome, 2024 - Springer
Background Fecal microbiota transplantation (FMT) and fecal virome transplantation (FVT,
sterile filtrated donor feces) have been effective in treating recurrent Clostridioides difficile …

Population-specific differences in the human microbiome: Factors defining the diversity

P Govender, M Ghai - Gene, 2024 - Elsevier
Differences in microbial communities at different body habitats define the microbiome
composition of the human body. The gut, oral, skin vaginal fluid and tissue microbiome, are …

[HTML][HTML] Animal and in vitro models as powerful tools to decipher the effects of enteric pathogens on the human gut microbiota

M Calvigioni, D Mazzantini, F Celandroni, E Ghelardi - Microorganisms, 2023 - mdpi.com
Examining the interplay between intestinal pathogens and the gut microbiota is crucial to
fully comprehend the pathogenic role of enteropathogens and their broader impact on …

Bioengineered probiotics: synthetic biology can provide live cell therapeutics for the treatment of foodborne diseases

KCP Cruz, LO Enekegho, DT Stuart - Frontiers in bioengineering and …, 2022 - frontiersin.org
The rising prevalence of antibiotic resistant microbial pathogens presents an ominous health
and economic challenge to modern society. The discovery and large-scale development of …

[HTML][HTML] Risk factors for Clostridioides difficile infection in children: a systematic review and meta-analysis

N Dong, ZR Li, P Qin, CX Qiang, J Yang, YN Niu… - Journal of Hospital …, 2022 - Elsevier
Background Clostridioides difficile is considered an urgent threat to human health by the US
Centers for Disease Control and Prevention. In recent years, C. difficile has been reported …

Epidemiological and microbiome associations of Clostridioides difficile carriage in infancy and early childhood

J Mani, S Levy, A Angelova, S Hazrati, R Fassnacht… - Gut …, 2023 - Taylor & Francis
There has been an increase in the prevalence of Clostridioides difficile (C. diff) causing
significant economic impact on the health care system. Although toxigenic C. diff carriage is …

[HTML][HTML] Gut Microbiota and New Microbiome-Targeted Drugs for Clostridioides difficile Infections

A Lee, JS Yoo, EJ Yoon - Antibiotics, 2024 - mdpi.com
Clostridioides difficile is a major causative pathogen for antibiotic-associated diarrhea and
C. difficile infections (CDIs) may lead to life-threatening diseases in clinical settings. Most of …