Current tuberculosis (TB) drug development efforts are not sufficient to end the global TB
epidemic. Recent efforts have focused on the development of whole-cell screening assays …

Antimicrobial resistance is a leading mortality factor worldwide. Here, we report the
discovery of clovibactin, an antibiotic isolated from uncultured soil bacteria. Clovibactin …

Streptomyces species are soil-dwelling bacteria that produce vast numbers of
pharmaceutically valuable secondary metabolites (SMs), such as antibiotics …

The cell walls of pathogenic and acidophilic bacteria, such as Mycobacterium tuberculosis
and Mycobacterium leprae, contain lipoarabinomannan and arabinogalactan. These …

Therapeutic treatment options for opportunistic non-tuberculous mycobacterial (NTM)
infection and/or serious mycobacterial infections such as tuberculosis (TB) and leprosy are …

Tuberculosis (TB) is one of the leading infectious diseases of global concern, and one
quarter of the world's population are TB carriers. Biotin metabolism appears to be an …

Cholesterol catabolism is an important survival mechanism for the pathogenic
Mycobacterium tuberculosis. Various other mycobacteria degrade not only cholesterol but …

Background Tuberculosis (TB) is caused by Mycobacterium tuberculosis and represents one
of the major challenges facing drug discovery initiatives worldwide. The considerable rise in …

Macrophages are the primary host cell type for infection by Mycobacterium tuberculosis in
vivo. Macrophages are also key immune effector cells that mediate the control of bacterial …

Mycobacterium smegmatis is a bacterium that is naturally devoid of known postreplicative
DNA mismatch repair (MMR) homologs, mutS and mutL, providing an opportunity to …