The silent information regulator sirtuin 1 (SIRT1) protein, a highly conserved NAD+-
dependent deacetylase belonging to the sirtuin family, is a post-translational regulator that …

The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …

Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a
serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the …

Precise regulation of the NFAT (nuclear factor of activated T cells) family of transcription
factors (NFAT1–4) is essential for vertebrate development and function. In resting cells …

Genotoxic stress exerts biological activity by activating downstream effectors, including the
p53 tumor suppressor. p53 regulates cell-cycle checkpoint and induction of apoptosis in …

DYRK1A is the human orthologue of the Drosophila minibrain (mnb) gene, which is involved
in postembryonic neurogenesis in flies. Because of its map** position on chromosome 21 …

Background Diabetes is a metabolic disorder characterized by chronic hyperglycaemia.
Chronic metabolic abnormalities and long-term hyperglycaemia may result in a wide range …

Autophosphorylation of a critical residue in the activation loop of several protein kinases is
an essential maturation event required for full enzyme activity. However, the molecular …

Dual‐specificity tyrosine phosphorylation‐regulated kinase 1A (DYRK1A) is a protein kinase
with diverse functions in neuronal development and adult brain physiology. Higher than …

This review article illustrates the growing use of azaindole derivatives as kinase inhibitors
and their contribution to drug discovery and innovation. The different protein kinases which …