The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

K Dheda, T Gumbo, G Maartens, KE Dooley… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults

KR Steingart, H Sohn, I Schiller… - Cochrane database …, 2013 - cochranelibrary.com
Background Accurate and rapid detection of tuberculosis (TB) and drug resistance are
critical for improving patient care and decreasing the spread of TB. Xpert® MTB/RIF assay …

HIV-associated opportunistic CNS infections: pathophysiology, diagnosis and treatment

LN Bowen, B Smith, D Reich, M Quezado… - Nature Reviews …, 2016 - nature.com
Nearly 30 years after the advent of antiretroviral therapy (ART), CNS opportunistic infections
remain a major cause of morbidity and mortality in HIV-positive individuals. Unknown HIV …

Management of patients with multidrug-resistant/extensively drug-resistant tuberculosis in Europe: a TBNET consensus statement

C Lange, I Abubakar, JWC Alffenaar, G Bothamley… - 2014 - publications.ersnet.org
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR)
tuberculosis (TB) substantially challenges TB control, especially in the European Region of …

Resistance to fluoroquinolones and second-line injectable drugs: impact on multidrug-resistant TB outcomes

D Falzon, N Gandhi, GB Migliori… - European …, 2013 - publications.ersnet.org
A meta-analysis for response to treatment was undertaken using individual data of multidrug-
resistant tuberculosis (MDR-TB)(resistance to isoniazid and rifampicin) patients from 26 …

Global epidemiology of tuberculosis

P Glaziou, C Sismanidis… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Despite the availability of effective chemotherapy, tuberculosis (TB) killed 1.3 million people
in 2012. Alongside HIV, it remains a top cause of death from an infectious disease. Global …

Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis

K Dheda, T Gumbo, NR Gandhi, M Murray… - The lancet Respiratory …, 2014 - thelancet.com
Extensively drug-resistant tuberculosis is a burgeoning global health crisis mainly affecting
economically active young adults, and has high mortality irrespective of HIV status. In some …

Drug-resistant tuberculosis: time for visionary political leadership

I Abubakar, M Zignol, D Falzon… - The Lancet infectious …, 2013 - thelancet.com
Two decades ago, WHO declared tuberculosis a global emergency, and invested in the
highly cost-effective directly observed treatment short-course programme to control the …

Rapid molecular TB diagnosis: evidence, policy making and global implementation of Xpert MTB/RIF

K Weyer, F Mirzayev, GB Migliori… - European …, 2013 - publications.ersnet.org
If tuberculosis (TB) is to be eliminated as a global health problem in the foreseeable future,
improved detection of patients, earlier diagnosis and timely identification of rifampicin …

Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis

JS Zifodya, JS Kreniske, I Schiller… - Cochrane Database …, 2021 - cochranelibrary.com
Background Xpert MTB/RIF and Xpert MTB/RIF Ultra (Xpert Ultra) are World Health
Organization (WHO)‐recommended rapid tests that simultaneously detect tuberculosis and …