Bioactive sphingolipids as emerging targets for signal transduction in cancer development

W Jia, J Yuan, J Zhang, S Li, W Lin, B Cheng - Biochimica et Biophysica …, 2024 - Elsevier
Sphingolipids, crucial components of cellular membranes, play a vital role in maintaining
cellular structure and signaling integrity. Disruptions in sphingolipid metabolism are …

Continuum models of membrane fusion: Evolution of the theory

SA Akimov, RJ Molotkovsky, PI Kuzmin… - International journal of …, 2020 - mdpi.com
Starting from fertilization, through tissue growth, hormone secretion, synaptic transmission,
and sometimes morbid events of carcinogenesis and viral infections, membrane fusion …

Are There Lipid Membrane-Domain Subtypes in Neurons with Different Roles in Calcium Signaling?

AK Samhan-Arias, J Poejo, D Marques-da-Silva… - Molecules, 2023 - mdpi.com
Lipid membrane nanodomains or lipid rafts are 10–200 nm diameter size cholesterol-and
sphingolipid-enriched domains of the plasma membrane, gathering many proteins with …

Elastic deformations mediate interaction of the raft boundary with membrane inclusions leading to their effective lateral sorting

KV Pinigin, OV Kondrashov, I Jiménez-Munguía… - Scientific Reports, 2020 - nature.com
Liquid-ordered lipid domains represent a lateral inhomogeneity in cellular membranes.
These domains have elastic and physicochemical properties different from those of the …

Toxic effects of penetrating cations

S Sokolov, A Zyrina, S Akimov, D Knorre, F Severin - Membranes, 2023 - mdpi.com
As mitochondria are negatively charged organelles, penetrating cations are used as parts of
chimeric molecules to deliver specific compounds into mitochondria. In other words, they are …

Organization of gangliosides into membrane nanodomains

MJ Sarmento, JC Ricardo, M Amaro, R Šachl - FEBS letters, 2020 - Wiley Online Library
Gangliosides are glycosphingolipids consisting of a ceramide base and a bulky sugar chain
that contains one or more sialic acids. This unique structure endows gangliosides with a …

Ordered lipid domains assemble via concerted recruitment of constituents from both membrane leaflets

A Saitov, SA Akimov, TR Galimzyanov, T Glasnov… - Physical review …, 2020 - APS
Lipid rafts serve as anchoring platforms for membrane proteins. Thus far they escaped direct
observation by light microscopy due to their small size. Here we used differently colored …

Membrane-mediated interaction of amphipathic peptides can be described by a one-dimensional approach

OV Kondrashov, TR Galimzyanov, I Jiménez-Munguía… - Physical Review E, 2019 - APS
Amphipathic alpha-helical peptides, among other peripheral components of plasma
membranes, are promising antimicrobial agents. Partial incorporation of a peptide into a …

The cytoplasmic tail of influenza A virus hemagglutinin and membrane lipid composition change the mode of M1 protein association with the lipid bilayer

LV Kordyukova, PV Konarev, NV Fedorova… - Membranes, 2021 - mdpi.com
Influenza A virus envelope contains lipid molecules of the host cell and three integral viral
proteins: major hemagglutinin, neuraminidase, and minor M2 protein. Membrane-associated …

Amphipathic peptides impede lipid domain fusion in phase-separated membranes

KV Pinigin, TR Galimzyanov, SA Akimov - Membranes, 2021 - mdpi.com
Cell membranes are heterogeneous in lipid composition which leads to the phase
separation with the formation of nanoscopic liquid-ordered domains, also called rafts. There …