Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Reactive species, which mainly include reactive oxygen species (ROS), are products
generated as a consequence of metabolic reactions in the mitochondria of eukaryotic cells …

Curative cancer therapy remains a major challenge particularly in cancers displaying
multidrug resistance (MDR). The MDR phenotype is characterized by cross-resistance to a …

The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and
resistance have been challenged in brain tumors. Here we report that cells expressing CSC …

The maintenance and repair of many adult tissues are ensured by stem cells (SCs), which
reside at the top of the cellular hierarchy of these tissues. Functional assays, such as in vitro …

Hypoxia induicible factor-1 alpha (HIF-1α) is a key transcription factor in cancer progression
and target therapy in cancer. HIF-1α acts differently depending on presence or absence of …

Despite the abundant ongoing research efforts, cancer remains one of the most challenging
diseases to treat globally. Due to the heterogenous nature of cancer, one of the major …

Glioblastoma is the most common and lethal primary malignant brain tumor in adults.
Patients die from recurrent tumors that have become resistant to therapy. New strategies are …

Hypoxia is a hallmark of all solid tumors and their metastases. This leads to activation of the
hypoxia-inducible factor (HIF) family of transcription factors, which modulate gene …